2. Apoptosis
  3. Bcl-2 Family Apoptosis
  4. Bcl-2-IN-10

Bcl-2-IN-10 是一种有活性的 Bcl-2 抑制剂，可释放多达四个一氧化氮 (NO) 分子。Bcl-2-IN-10 对人类白血病、乳腺癌和肺癌等癌细胞具有细胞毒性。Bcl-2-IN-10 可诱导细胞凋亡 (apopotosis)，阻滞细胞周期在 G2/M 期，可用于癌症相关的研究。

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Bcl-2-IN-10 Chemical Structure

Bcl-2-IN-10 Chemical Structure

CAS No. : 2773354-28-0

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Bcl-2-IN-10 相关抗体

Top Publications Citing Use of Products

查看 Bcl-2 Family 亚型特异性产品:

查看所有亚型
Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Bcl-2-IN-10 is an active Bcl-2 inhibitor that can release up to four nitric oxide (NO) molecules. Bcl-2-IN-10 has cytotoxic activities against cancer cells, such as human leukemia, breast cancer and lung cancer. Bcl-2-IN-10 induces cell apopotosis and arrest cell cycle of G2/M phase, and can be used in cancer-related research[1].

IC50 & Target[1]

Bax

 

体外研究
(In Vitro)

Steroid sulfatase-IN-2 (compound 1, 0-20 μM approximately, 72 h) inhibits different cancer cells with IC50s ranging from 1.26 μM to 17.86 μM[1].
Steroid sulfatase-IN-2 (1 μM, 5 h) releases up to four molecules of nitric oxide[1].
Steroid sulfatase-IN-2 (8 μM, 8-72 h) induces leukemia cell CCRF-CEM apoptosis via MAPKs pathways, arrests cell in the G2/M phase, and increases ratio of Bax/Bcl-2[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Bcl-2-IN-10 相关抗体:

Apoptosis Analysis[1]

Cell Line: CEM cells
Concentration: 8 μM
Incubation Time: 8, 24, 48 or 72 h
Result: Induced apoptosis in a time-dependent and dose-dependent manner.

Cell Cycle Analysis[1]

Cell Line: CEM cells
Concentration: 8 μM
Incubation Time: 8, 24, 48 or 72 h
Result: Arrested cell in the G2/M phase.

Western Blot Analysis[1]

Cell Line: CEM cells
Concentration: 0-8 μM
Incubation Time: 72 h
Result: Increased the levels of JNK and p38, and the levels of phosphorylated JNK and p38.
Decreased Bcl-2 level in a time- and dose-dependent manner, and increased pro-apoptotic Bax level.
分子量

635.50

Formula

C22H25N11O12
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Bcl-2-IN-10 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Bcl-2-IN-102773354-28-0Bcl-2 FamilyApoptosisDDNO derivativesanti-cancerNOapopotosisBax/Bcl-2MAPKInhibitorinhibitorinhibit

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