2. Gene
  3. FRAT1 - FRAT regulator of WNT signaling pathway 1 Gene

FRAT1 - FRAT regulator of WNT signaling pathway 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 直系同源

中文名称：WNT 信号通路 1 的 FRAT 调节器

种属: Homo sapiens

基因 ID: 10023 | 基因类型: protein coding

关于 FRAT1

Cytogenetic location: 10q24.1 Genomic coordinates (GRCh38): 10:97,319,271-97,321,915 (from NCBI)

This gene has 2 transcripts (splice variants), 63 orthologues and 1 paralogue.

功能概要

该基因编码的蛋白质属于 GSK-3 结合蛋白家族。该蛋白抑制 GSK-3 介导的 β-连环蛋白磷酸化并正向调节 Wnt 信号通路。它可能在肿瘤进展和淋巴瘤形成中发挥作用。[RefSeq 提供，2008 年 10 月]

The protein encoded by this gene belongs to the GSK-3-binding protein family. The protein inhibits GSK-3-mediated phosphorylation of beta-catenin and positively regulates the Wnt signaling pathway. It may function in tumor progression and in lymphomagenesis. [provided by RefSeq, Oct 2008]

FRAT1 基因产物(1)

mRNA Protein Name
NM_005479.4 NP_005470.2 proto-oncogene FRAT1

FRAT1 蛋白结构

GSK-3_bind

GSK-3_bind: Glycogen synthase kinase-3 binding (1 - 239)

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  • 279 a.a.
蛋白主名 其他名称

proto-oncogene FRAT1

FRAT-1

关联疾病

疾病名称 别名
Hepatocellular Carcinoma

Liver Cancer

Primary Liver Cancer

HCC

Hepatoma

Malignant Neoplasm Of Liver

Liver Neoplasms

Cancer, Hepatocellular

Liver Cell Carcinoma

Lcc

Hepatoblastoma, Somatic

Hepatic Cancer

Primary Malignant Neoplasm Of Liver

Rare Tumor Of Liver And Intrahepatic Biliary Tract

Hepatocellular Carcinoma, Somatic

Hepatocellular Carcinoma, Childhood Type, Somatic

Hepatocellular Cancer, Somatic

Ca Liver - Primary

Hepatic Neoplasm

Malignant Hepato-Biliary Neoplasm

Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

Malignant Neoplasm Of Liver, Primary

Malignant Tumor Of Liver

Neoplasm Of Liver

Non-Resectable Primary Hepatic Malignant Neoplasm

Resectable Malignant Neoplasm Of Liver

Resectable Malignant Neoplasm Of The Liver

Primary Liver Carcinoma

Primary Malignant Liver Neoplasm

Primary Cancer Of Liver

Primary Tumor Of The Liver

Rare Tumor Of Liver And Ibt

Hepatocellular Cancer

Neoplasm Of The Liver

Carcinoma, Hepatocellular

Hepatomas

Liver Neoplasm

Liver Carcinoma

Liver And Intrahepatic Biliary Tract Carcinoma

Malignant Hepatobiliary Neoplasm

Adult Primary Hepatocellular Carcinoma

Hepatoblastoma

Carcinoma Of Liver

Malignant Liver Tumour

Malignant Hepatic Tumour
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta FRAT1 VGNC VGNC:72816
Mus musculus FRAT1 MGD MGI:109450
Bos taurus FRAT1 VGNC VGNC:55951
Rattus norvegicus FRAT1 RGD RGD:9147096