2. Gene
  3. CHAF1A - chromatin assembly factor 1 subunit A Gene

CHAF1A - chromatin assembly factor 1 subunit A Gene

  • 基因
  • 蛋白
  • 疾病
  • 直系同源

中文名称：染色质装配因子 1 亚基 A

种属: Homo sapiens

同用名: CAF1; P150; CAF-1; CAF1B; CAF1P150

基因 ID: 10036 | 基因类型: protein coding

关于 CHAF1A

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,402,640-4,450,830 (from NCBI)

This gene has 7 transcripts (splice variants) and 200 orthologues. Broad expression in bone marrow (RPKM 7.4), testis (RPKM 6.1) and 24 other tissues.

功能概要

染色质组装因子 I (CAF1) 是一种核复合物，由 p50、p60 (CHAF1B；MIM 601245) 和 p150 (CHAF1A) 亚基组成，可在体外将组蛋白八聚体组装到复制 DNA 上 (Kaufman 等人，1995 [PubMed 7600578]) .[OMIM 提供，2008 年 3 月]

Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]

CHAF1A 基因产物(1)

mRNA Protein Name
NM_005483.3 NP_005474.2 chromatin assembly factor 1 subunit A

CHAF1A 蛋白结构

CAF1-p150_N

CAF1-p150_N: CAF1 complex subunit p150, region binding to PCNA (1 - 229)

CAF-1_p150

CAF-1_p150: Chromatin assembly factor 1 complex p150 subunit, N-terminal (267 - 479)

CAF1A

CAF1A: Chromatin assembly factor 1 subunit A (557 - 634)

CAF1-p150_C2

CAF1-p150_C2: CAF1 complex subunit p150, region binding to CAF1-p60 at C-term (665 - 956)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 956 a.a.
蛋白主名 其他名称

chromatin assembly factor 1 subunit A

CAF-1 subunit A

关联疾病

疾病名称 别名
Prostate Squamous Cell Carcinoma

Squamous Cell Carcinoma Of Prostate
Digeorge Syndrome

Chromosome 22q11.2 Deletion Syndrome

DGS

Hypoplasia Of Thymus And Parathyroids

Third And Fourth Pharyngeal Pouch Syndrome

22q11.2 Deletion Syndrome

Digeorge Sequence

Digeorge'S Syndrome

Pharyngeal Pouch Syndrome

Di-George Syndrome

Shprintzen Syndrome
Alpha Thalassemia-Intellectual Disability Syndrome Type 1

Alpha Thalassemia-Intellectual Disability Syndrome, Deletion Type

Alpha-Thalassemia-Intellectual Disability Syndrome Linked To Chromosome 16

Atr Syndrome Linked To Chromosome 16

Atr Syndrome, Deletion Type

Atr-16 Syndrome

Alpha Thalassemia-Retardation Syndrome

Alpha-Thalassemia/Mental Retardation Syndrome, Deletion-Type

Alpha-Thalassemia/Mental Retardation Syndrome, Type 1

Alpha-Thalassemia Mental Retardation Syndrome, Deletion-Type
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CHAF1A RGD RGD:1590865
Canis familiaris CHAF1A VGNC VGNC:39189
Bos taurus CHAF1A VGNC VGNC:27266
Felis catus CHAF1A VGNC VGNC:60835
Macaca mulatta CHAF1A VGNC VGNC:71024
Mus musculus CHAF1A MGD MGI:1351331