H3C14 - H3 clustered histone 14 Gene

中文名称：H3 成簇组蛋白 14

种属: Homo sapiens

同用名: H3; H3.2; H3/M; H3F2; H3FM; H3FN; H3C13; H3C15; HIST2H3C

关于 H3C14

功能概要

组蛋白是基本的核蛋白，负责真核生物染色体纤维的核小体结构。这种结构由大约 146 bp 的 DNA 组成，核小体是一个八聚体，由四种核心组蛋白 (H2A、H2B、H3 和 H4) 中的每一种成对组成。染色质纤维通过接头组蛋白 H1 与核小体之间的 DNA 相互作用进一步压缩，形成更高阶的染色质结构。该基因是无内含子的，编码复制依赖组蛋白，该组蛋白是组蛋白 H3 家族的成员。该基因的转录本缺少 polyA 尾巴；相反，它们包含回文终止元素。该基因存在于 1 号染色体上的组蛋白簇中。该基因是簇中复制的四个组蛋白基因之一；该记录代表端粒拷贝。[RefSeq 提供，2015 年 8 月]

Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H3 family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]