PTPRU - protein tyrosine phosphatase receptor type U Gene

中文名称：U 型蛋白酪氨酸磷酸酶受体

种属: Homo sapiens

同用名: FMI; PTP; PCP-2; PTP-J; PTPRO; PTPU2; PTP-PI; PTP-RO; PTPPSI; hPTP-J; R-PTP-U; R-PTP-PSI

关于 PTPRU

功能概要

该基因编码的蛋白质是蛋白酪氨酸磷酸酶 (PTP) 家族的成员。已知 PTP 是调节多种细胞过程的信号分子，包括细胞生长、分化、有丝分裂周期和致癌转化。该 PTP 具有细胞外区域、单个跨膜区域和两个串联的细胞内催化结构域，因此代表受体型 PTP。细胞外区域包含安眠蛋白-A5 抗原-PTP (MAM) 结构域、Ig 样和纤连蛋白 III 型样重复序列。该 PTP 被认为在细胞间识别和粘附中发挥作用。对小鼠中相似基因的研究表明这种 PTP 在早期神经发育中的作用。据报道，该基因的表达受 Jurkat T 淋巴瘤细胞中佛波醇肉豆蔻酸酯醋酸盐 (PMA) 或钙离子载体的调节。已经报道了可变剪接的转录物变体。[RefSeq 提供，2010 年 8 月]

The protein encoded by this gene is a member of the protein tyrosine Phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracellular catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP (MAM) domain, Ig-like and fibronectin type III-like repeats. This PTP was thought to play roles in cell-cell recognition and adhesion. Studies of the similar gene in mice suggested the role of this PTP in early neural development. The expression of this gene was reported to be regulated by phorbol myristate acetate (PMA) or calcium ionophore in Jurkat T lymphoma cells. Alternatively spliced transcript variants have been reported. [provided by RefSeq, Aug 2010]