1. Gene
  2. SGK2 - serum/glucocorticoid regulated kinase 2 Gene

SGK2 - serum/glucocorticoid regulated kinase 2 Gene

中文名称:血清/糖皮质激素调节激酶 2

种属: Homo sapiens

同用名: H-SGK2; dJ138B7.2

基因 ID: 10110 | 基因类型: protein coding

关于 SGK2

Cytogenetic location: 20q13.12 Genomic coordinates (GRCh38): 20:43,559,027-43,585,627 (from NCBI)

This gene has 14 transcripts (splice variants), 199 orthologues and 13 paralogues. Biased expression in kidney (RPKM 17.8), colon (RPKM 13.6) and 8 other tissues.

功能概要

该基因编码丝氨酸/苏氨酸蛋白激酶。尽管该基因产物类似于血清和糖皮质激素诱导的蛋白激酶 (SGK) ,但该基因不是由血清或糖皮质激素诱导的。该基因响应于激活磷脂酰肌醇 3-激酶的信号而被诱导,这对于 SGK 也是如此。可变剪接导致多个转录本变体。[RefSeq 提供,2010 年 11 月]

This gene encodes a serine/threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this gene is not induced by serum or glucocorticoids. This gene is induced in response to signals that activate phosphatidylinositol 3-kinase, which is also true for SGK. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2010]

SGK2 基因产物(3)

mRNA Protein Name
NM_001199264.2 NP_001186193.1 serine/threonine-protein kinase Sgk2
NM_016276.5 NP_057360.3 serine/threonine-protein kinase Sgk2
NM_170693.3 NP_733794.1 serine/threonine-protein kinase Sgk2
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables potassium channel regulator activity IDA
IDA: 通过直接分析推断
12397388 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
22939624 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

SGK2 蛋白结构

Pkinase

Pkinase: Protein kinase domain (96 - 352)

Pkinase_C

Pkinase_C: Protein kinase C terminal domain (372 - 420)

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  • 427 a.a.
蛋白主名 其他名称

serine/threonine-protein kinase Sgk2

SGK2, serine/threonine kinase 2

SGK2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SGK2 Q9HBY8 HSP90AB1 Homo sapiens P08238 32707033
种属内
SGK2 Q9HBY8 HSP90AB1 Homo sapiens P08238 22939624
种属内
SGK2 Q9HBY8 HSP90AB1 Homo sapiens P08238 33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon

Noonan Syndrome 1

Noonan Syndrome

NS1

Male Turner Syndrome

Female Pseudo-Turner Syndrome

Turner Phenotype With Normal Karyotype

Noonan Syndrome With Pigmented Villonodular Synovitis

Turner'S Phenotype, Karyotype Normal

Familial Turner Syndrome

Noonan'S Syndrome

Noonan-Ehmke Syndrome

Ns

Pseudo-Ullrich-Turner Syndrome

Turner Syndrome In Female With X Chromosome

Turner-Like Syndrome

Ullrich-Noonan Syndrome

Noonan-Like/Multiple Giant Cell Lesion Syndrome

Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions

Pterygium Colli Syndrome

Noonan Syndrome, Type 1

Turner Syndrome, Male

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Felis catus SGK2 VGNC VGNC:65079
Rattus norvegicus SGK2 RGD RGD:620232
Macaca mulatta SGK2 VGNC VGNC:77228
Mus musculus SGK2 MGD MGI:1351318
Bos taurus SGK2 VGNC VGNC:34542
Others SGK2 NCBI