1. Signaling Pathways
  2. Metabolic Enzyme/Protease
  3. SGK

SGK

Serum- and glucocorticoid-inducible kinase 1 (SGK1) is a member of the Ser/Thr protein kinase family that regulates a variety of cell functions. SGK1 may regulate the cell cycle through the modulation of microtubule (MT) dynamics in tumor cells. SGK1 depolymerizes MTs through two distinct mechanisms both in vitro and in vivo. First, SGK1 directly depolymerizes MT independently of its kinase activity. Second, SGK1 depolymerizes MT through the phosphorylation of tau specifically at Ser214.

SGK1 is under regulation of several hormones, mediators and cell stressors. SGK1 is cloned as a gene up-regulated by serum and glucocorticoids in rat mammary tumor cells.

SGK1 is transcriptionally upregulated by mineralocorticoids and activated by insulin. The kinase enhances renal tubular Na+-reabsorption and accounts for blood pressure increase following high salt diet in mice made hyperinsulinemic by dietary fructose or fat.

SGK 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-15193
    EMD638683 Inhibitor 99.74%
    EMD638683 是具有高度选择性的 SGK1 抑制剂,IC50 值为 3 μM。
  • HY-15192
    GSK 650394 Inhibitor 99.38%
    GSK 650394 是一种新颖的 SGK 抑制剂,在SPA实验中,对 SGK1 和 SGK2 的IC50 分别为 62 nM 和 103 nM。
  • HY-15193A
    EMD638683 R-Form Inhibitor 99.68%
    EMD638683 R-Form 是 EMD638683 的 R 型异构体。EMD638683 是一种选择性的 SGK1 抑制剂。
  • HY-15193B
    EMD638683 S-Form Inhibitor 98.30%
    EMD638683 (S-Form)是SGK1抑制剂,IC50> 300 nM。
  • HY-125878
    PROTAC SGK3 degrader-1 Inhibitor
    PROTAC SGK3 degrader-1 (SGK3-PROTAC1) 是一种基于 PROTACSKG3 降解剂。PROTAC SGK3 degrader-1 (0.3 μM) 在 2 小时内诱导 50% 内源性 SGK3 降解,8 小时观察到 80%SGK3 的降解,并伴随着 NDRG1 (SGK3 底物) 的磷酸化损失 [1]
  • HY-18607
    SGK1-IN-1 Inhibitor
    SGK1-IN-1 是高活性的、血清和糖皮质激素调节激酶 1 (SGK-1) 的选择性抑制剂,其 IC50 值为 1 nM。
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