1. Gene
  2. G3BP1 - G3BP stress granule assembly factor 1 Gene

G3BP1 - G3BP stress granule assembly factor 1 Gene

中文名称:G3BP 应力颗粒装配因子 1

种属: Homo sapiens


基因 ID: 10146 | 基因类型: protein coding

关于 G3BP1

Cytogenetic location: 5q33.1 Genomic coordinates (GRCh38): 5:151,771,954-151,812,785 (from NCBI)

This gene has 78 transcripts (splice variants), 238 orthologues and 1 paralogue. Ubiquitous expression in lymph node (RPKM 18.3), appendix (RPKM 16.8) and 25 other tissues.


该基因编码一种 DNA 解旋酶,它更倾向于部分解旋的 3' 尾底物,也可以以 ATP 依赖性方式解旋部分 RNA/DNA 和 RNA/RNA 双链体。这种酶是异质核 RNA 结合蛋白的成员,也是 Ras 信号转导通路的一个组成部分。它通过与其 SH3 结构域相关联而特异性结合 Ras-GTPase 激活蛋白。已经描述了该基因的几种可变剪接的转录本变体,但尚未确定其中一些变体的全长性质。[RefSeq 提供,2008 年 7 月]

This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]

G3BP1 基因产物(2)

mRNA Protein Name
NM_005754.3 NP_005745.1 ras GTPase-activating protein-binding protein 1
NM_198395.2 NP_938405.1 ras GTPase-activating protein-binding protein 1

G3BP1 蛋白结构


NTF2: Nuclear transport factor 2 (NTF2) domain (11 - 133)


RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (342 - 396)

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蛋白主名 其他名称

ras GTPase-activating protein-binding protein 1

ATP-dependent DNA helicase VIII


疾病名称 别名

Chikungunya Fever

Arbovirus A Chikungunya Type


Chikv Infection


Chikungunya Virus Infection

Chikungunya Haemorrhagic Fever

Chikungunya Viral Disease

Chikungunya Mosquito-Borne Viral Fever

Mouth Disease

Mouth Diseases

Mouth Disorders

Multisystem Proteinopathy
Epithelial-Stromal Tgfbi Dystrophy
Lattice Corneal Dystrophy

Familial Amyloid Neuropathy, Finnish Type

Familial Amyloid Polyneuropathy, Type V

Frontotemporal Dementia

Pallidopontonigral Degeneration

Frontotemporal Lobar Degeneration

Semantic Dementia


Frontotemporal Lobe Dementia

Multiple System Tauopathy With Presenile Dementia

Dementia, Frontotemporal

Frontotemporal Dementia With Parkinsonism


Frontotemporal Lobar Degeneration With Tau Inclusions

Ftld With Tau Inclusions

Dementia, Frontotemporal, With Parkinsonism



Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex


Wilhelmsen-Lynch Disease



Dementia, Frontotemporal, With Or Without Parkinsonism

Semantic Primary Progressive Aphasia

Semantic Variant Ppa

Wilhemsen-Lynch Disease

Frontotemporal Dementia-Amyotrophic Lateral Sclerosis

Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17



Pick Complex

Pick Disease Of The Brain

Frontotemporal Dementia With Parkinsonism-17

Grn-Related Frontotemporal Dementia

Frontotemporal Dementia With Motor Neuron Disease

Dementia In Fronto-Temporal Lobar Degeneration

Ftd - [Frontotemporal Dementia]

Temple Dementia

Frontal Lobe Dementia

Amyotrophic Lateral Sclerosis 1

Amyotrophic Lateral Sclerosis


Lou Gehrig Disease

Amyotrophic Lateral Sclerosis Type 1

Charcot Disease


Amyotrophic Lateral Sclerosis, Susceptibility To


Lou Gehrig'S Disease


Motor Neuron Disease

Familial Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis 1, Familial

Amyotrophic Lateral Sclerosis 1, Autosomal Dominant

Motor Neuron Disease, Bulbar

Motor Neurone Disease

Amyotrophic Lateral Sclerosis With Dementia

Dementia With Amyotrophic Lateral Sclerosis

Motor Neuron Disease, Amyotrophic Lateral Sclerosis

Sclerosis, Lateral, Amyotrophic

Sclerosis, Lateral, Amyotrophic, Type 1

Amyotrophic Sclerosis

Als - [Amyotrophic Lateral Sclerosis]

Wasting Palsy

Amyotrophic Paralysis

Amyotrophy Lateral Sclerosis

Wasting Paralysis

Spinal Progressive Amyotrophy

Progressive Atrophic Paralysis

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma


种属 基因名 来源 基因 ID
Canis familiaris G3BP1 VGNC VGNC:41038
Rattus norvegicus G3BP1 RGD RGD:621140
Mus musculus G3BP1 MGD MGI:1351465
Macaca mulatta G3BP1 VGNC VGNC:72810
Felis catus G3BP1 VGNC VGNC:97440
Bos taurus G3BP1 VGNC VGNC:29176