AGR2 - anterior gradient 2, protein disulphide isomerase family member Gene

中文名称：前梯度 2，蛋白质二硫化物异构酶家族成员

种属: Homo sapiens

同用名: AG2; AG-2; HPC8; GOB-4; HAG-2; XAG-2; PDIA17; HEL-S-116

基因 ID: 10551 | 基因类型: protein coding

关于 AGR2

Cytogenetic location: 7p21.1 Genomic coordinates (GRCh38): 7:16,791,811-16,804,999 (from NCBI)

This gene has 7 transcripts (splice variants), 211 orthologues and 2 paralogues. Biased expression in stomach (RPKM 530.9), colon (RPKM 321.4) and 6 other tissues.

功能概要

该基因编码内质网 (ER) 蛋白二硫化物异构酶 (PDI) 家族的成员，该蛋白催化蛋白质折叠和硫醇-二硫化物交换反应。编码的蛋白质具有 N 端 ER 信号序列、催化活性硫氧还蛋白结构域和 C 端 ER 保留序列。这种蛋白质在细胞迁移、细胞转化和转移中发挥作用，是一种 p53 抑制剂。作为定位于 ER 的分子伴侣，它在富含半胱氨酸的跨膜受体和富含半胱氨酸的肠糖蛋白粘蛋白的折叠、运输和组装中发挥作用。该基因与炎症性肠病和癌症进展有关。[RefSeq 提供，2017 年 3 月]

This gene encodes a member of the disulfide isomerase (PDI) family of endoplasmic reticulum (ER) proteins that catalyze protein folding and thiol-disulfide interchange reactions. The encoded protein has an N-terminal ER-signal sequence, a catalytically active thioredoxin domain, and a C-terminal ER-retention sequence. This protein plays a role in cell migration, cellular transformation and metastasis and is as a p53 inhibitor. As an ER-localized molecular chaperone, it plays a role in the folding, trafficking, and assembly of cysteine-rich transmembrane receptors and the cysteine-rich intestinal gylcoprotein Mucin. This gene has been implicated in inflammatory bowel disease and Cancer progression. [provided by RefSeq, Mar 2017]

AGR2 基因产物(1)

mRNA	Protein	Name
NM_006408.4	NP_006399.1	anterior gradient protein 2 homolog precursor

AGR2 蛋白结构

Thioredoxin_7

0
100
175 a.a.

蛋白主名

其他名称

anterior gradient protein 2 homolog

anterior gradient homolog 2

重组 AGR2 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7465	AG-2 Protein, Human (HEK293, His)	O95994 (R21-L175)	≥95%
HY-P7465A	AG-2 Protein, Human (HEK293, C-His)	O95994 (R21-L175)	≥95%

关联疾病

疾病名称

别名

Ileocolitis

Iieocolitis

Inflammatory Bowel Disease

Inflammatory Bowel Diseases

Bowel Disease, Inflammatory

Non-Proliferative Fibrocystic Change Of The Breast

Non-Proliferative Fibrocystic Change

Breast Fibrocystic Change, Non-Proliferative Type

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Fibrolamellar Carcinoma

Fibrolamellar Hepatocellular Carcinoma	Fhcc
Fibrolamellar Hepatocarcinoma	Hepatocellular Carcinoma, Fibrolamellar
Oncocytic Hepatocellular Tumor	Eosinophilic Glassy Cell Hepatoma
Eosinophilic Hepatocellular Carcinoma With Lamellar Fibrosis	Fl-Hcc
Fibrolamellar Oncocytic Hepatoma	Hepatocellular Carcinoma With Increased Stromal Fibrosis
Polygonal Cell Hepatocellular Carcinoma With Fibrous Stroma

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS00462	AGR2 Human Pre-designed siRNA Set A		/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	AGR2	MGD	MGI:1344405
Bos taurus	AGR2	VGNC	VGNC:25740
Canis familiaris	AGR2	VGNC	VGNC:37715
Felis catus	AGR2	VGNC	VGNC:59690
Rattus norvegicus	AGR2	RGD	RGD:1304606
Macaca mulatta	AGR2	VGNC	VGNC:69748
Others	AGR2	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。沪(浦)应急管危经许[2021]201709(QFYS)

站点地图隐私声明

AGR2 - anterior gradient 2, protein disulphide isomerase family member Gene

关于 AGR2

功能概要

AGR2 基因产物(1)

AGR2 蛋白结构

重组 AGR2 蛋白

关联疾病

直系同源

热门区域

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AGR2 - anterior gradient 2, protein disulphide isomerase family member Gene

关于 AGR2

功能概要

AGR2 基因产物(1)

AGR2 蛋白结构

重组 AGR2 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z