1. Gene
  2. PSMA1 - proteasome 20S subunit alpha 1 Gene

PSMA1 - proteasome 20S subunit alpha 1 Gene

中文名称:蛋白酶体 20S 亚基 alpha 1

种属: Homo sapiens

同用名: NU; HC2; PROS30; HEL-S-275

基因 ID: 5682 | 基因类型: protein coding

关于 PSMA1

Cytogenetic location: 11p15.2 Genomic coordinates (GRCh38): 11:14,504,876-14,643,662 (from NCBI)

This gene has 14 transcripts (splice variants), 253 orthologues and 18 paralogues. Ubiquitous expression in appendix (RPKM 35.7), placenta (RPKM 35.1) and 25 other tissues.

功能概要

蛋白酶体是一种多催化蛋白酶复合物,具有高度有序的环状 20S 核心结构。核心结构由 28 个不同亚基的 4 个环组成; 2 个环由 7 个α亚基组成,2 个环由 7 个β亚基组成。蛋白酶体以高浓度分布在整个真核细胞中,并在非溶酶体途径中以 ATP/泛素依赖性过程切割肽。修饰的蛋白酶体 (免疫蛋白酶体) 的基本功能是加工 I 类 MHC 肽。该基因编码肽酶 T1A 家族的一个成员,即 20S 核心 alpha 亚基。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供,2009 年 1 月]

The Proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave Peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. An essential function of a modified Proteasome, the immunoproteasome, is the processing of class I MHC Peptides. This gene encodes a member of the peptidase T1A family, that is a 20S core alpha subunit. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Jan 2009]

PSMA1 基因产物(3)

mRNA Protein Name
NM_001143937.2 NP_001137409.1 proteasome subunit alpha type-1 isoform 3
NM_002786.4 NP_002777.1 proteasome subunit alpha type-1 isoform 2
NM_148976.3 NP_683877.1 proteasome subunit alpha type-1 isoform 1

PSMA1 蛋白结构

Proteasome_A_N

Proteasome_A_N: Proteasome subunit A N-terminal signature (6 - 28)

Proteasome

Proteasome: Proteasome subunit (29 - 215)

  • 0
  • 100
  • 200
  • 263 a.a.
蛋白主名 其他名称

proteasome subunit alpha type-1

30 kDa prosomal protein

关联疾病

疾病名称 别名
Mucocele Of Salivary Gland

Ranula

Salivary Cyst

Salivary Gland Mucocele

Mucous Retention Cyst Of Salivary Gland

Retention Cyst Of Salivary Gland

Sialocele

Cyst Of Salivary Gland Or Duct

Extravasation Cyst Of Salivary Gland

Anthracosilicosis
Castration-Resistant Prostate Carcinoma

Prostatic Neoplasms, Castration-Resistant

Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis

Lung Cancer

Lung Carcinoma

Non-Small Cell Lung Carcinoma

Lung Cancer, Susceptibility To

Lung Cancer, Protection Against

Adenocarcinoma Of Lung, Somatic

Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer

Lung Neoplasm

Carcinoma Of Lung

Lung Non-Small Cell Carcinoma

Non-Small Cell Lung Cancer

Nsclc

Lung Neoplasms

Malignant Neoplasm Of Lung

Alveolar Cell Carcinoma

Nonsmall Cell Lung Cancer, Somatic

Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In

Nonsmall Cell Lung Cancer, Susceptibility To

Lung Cancer, Somatic

Lung Cancer, Resistance To

Cancer Of Lung

Cancer Of Bronchus

Cancer Of The Lung

Lung Malignancies

Lung Malignant Tumors

Malignant Lung Tumor

Malignant Tumor Of Lung

Pulmonary Cancer

Pulmonary Carcinoma

Pulmonary Neoplasms

Respiratory Carcinoma

LNCR

Adenocarcinoma Of Lung

Neoplasm Of Lung

Cancer Lung

Carcinoma Non-Small Cell Lung

Carcinoma, Non-Small-Cell Lung

Lung Cancers

Lung Carcinomas

Cancer, Lung

Cancer, Lung, Non-Small Cell

Primary Malignant Neoplasm Of Lung

Bronchioloalveolar Adenocarcinoma

Breast Cancer

Breast Carcinoma

Male Breast Cancer

Breast Cancer, Familial

Malignant Neoplasm Of Breast

Breast Cancer, Susceptibility To

Breast Cancer, Early-Onset

Malignant Tumor Of Breast

Carcinoma Of Male Breast

Breast Cancer, Invasive Ductal

Breast Cancer, Protection Against

Breast Cancer, Somatic

Breast Cancer, Male

Breast Cancer, Lobular, Somatic

Breast Tumor

Mammary Cancer

Mammary Tumor

Malignant Neoplasm Of Male Breast

Mammary Carcinoma

Male Breast Carcinoma

Familial Cancer Of Breast

Invasive Ductal Breast Carcinoma

Breast Cancer Susceptibility

Breast Cancer, Male, Susceptibility To

Breast Cancer, Early-Onset, Susceptibility To

Malignant Tumor Of The Breast

Mammary Neoplasm

Primary Breast Cancer

Neoplasm Of Male Breast

Carcinoma Of Breast

Breast Cancer In Men

Familial Breast Cancer

Cancer Of Breast

BC

Breast Cancer Familial

Breast Cancer Familial Male

Breast Cancer, Familial Male

Breast Male Carcinoma

Breast Neoplasms

Breast Neoplasms, Male

Mammary Tumors

Mammary Carcinomas

Cancer, Breast

Cancer, Breast, Susceptibility

Invasive Breast Ductal Carcinoma

Breast Neoplasm

Susceptibility To Breast Cancer

Mammary Neoplasms

Animal Mammary Neoplasms

Primary Malignant Neoplasm Of Breast

Infiltrating Ductal Carcinoma Of Breast

Infiltrating Duct Carcinoma Of Unspecified Site

Infiltrating Ductular Carcinoma Of Unspecified Site

Invasive Breast Carcinoma Of No Special Type

Microinvasive Carcinoma Of Breast

Carcinoma With Apocrine Differentiation

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus PSMA1 RGD RGD:61841
Felis catus PSMA1 VGNC VGNC:81948
Bos taurus PSMA1 VGNC VGNC:97304
Mus musculus PSMA1 MGD MGI:1347005
Macaca mulatta PSMA1 VGNC VGNC:97813