POLQ - DNA polymerase theta Gene

中文名称：DNA 聚合酶θ

种属: Homo sapiens

同用名: PRO0327

基因 ID: 10721 | 基因类型: protein coding

关于 POLQ

Cytogenetic location: 3q13.33 Genomic coordinates (GRCh38): 3:121,431,431-121,545,988 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues, 8 paralogues and is associated with 90 phenotypes. Biased expression in bone marrow (RPKM 2.5), lymph node (RPKM 1.7) and 13 other tissues.

功能概要

启用催化活性，作用于 DNA；染色质结合活性；和相同的蛋白质结合活性。参与 DNA 修复；通过同源重组负调控双链断裂修复；和蛋白质同源寡聚化。位于高尔基体；胞质溶胶；和核质。 [由基因组资源联盟提供，2022 年 4 月]

Enables catalytic activity, acting on DNA; chromatin binding activity; and identical protein binding activity. Involved in DNA repair; negative regulation of double-strand break repair via homologous recombination; and protein homooligomerization. Located in Golgi apparatus; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]

POLQ 基因产物(1)

mRNA	Protein	Name
NM_199420.4	NP_955452.3	DNA polymerase theta

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables 5'-deoxyribose-5-phosphate lyase activity	IDA IDA: 通过直接分析推断	19188258	GOA
enables DNA helicase activity	IDA IDA: 通过直接分析推断	36455556	GOA
enables DNA-directed DNA polymerase activity	IDA IDA: 通过直接分析推断	14576298	GOA
enables DNA-directed DNA polymerase activity	IMP IMP: 通过突变表型推断	22135286	GOA
enables chromatin binding	IDA IDA: 通过直接分析推断	25642963	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	26636256	GOA
enables magnesium ion binding	IDA IDA: 通过直接分析推断	25775267	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25642963	GOA
enables single-stranded DNA helicase activity	IDA IDA: 通过直接分析推断	14576298	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in DNA damage response	IDA IDA: 通过直接分析推断	25642963	GOA
involved in base-excision repair	IDA IDA: 通过直接分析推断	19188258	GOA
involved in double-strand break repair	IDA IDA: 通过直接分析推断	22135286	GOA
involved in double-strand break repair via alternative nonhomologous end joining	IDA IDA: 通过直接分析推断	25643323	GOA
involved in error-prone translesion synthesis	IDA IDA: 通过直接分析推断	30655289	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IDA IDA: 通过直接分析推断	25642963	GOA
involved in negative regulation of double-strand break repair via homologous recombination	IMP IMP: 通过突变表型推断	28695890	GOA
involved in protein homooligomerization	IDA IDA: 通过直接分析推断	25643323	GOA
involved in replication fork processing	IDA IDA: 通过直接分析推断	30655289	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
is active in mitochondrial nucleoid	IDA IDA: 通过直接分析推断	29509408	GOA
is active in nucleus	IDA IDA: 通过直接分析推断	29509408	GOA
is active in site of DNA damage	IDA IDA: 通过直接分析推断	34179826	GOA
is active in site of double-strand break	IDA IDA: 通过直接分析推断	37440612	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

POLQ 蛋白结构

DEAD

Helicase_C

HHH_5

DNA_pol_A

0
400
800
1200
1600
2000
2400
2590 a.a.

蛋白主名

其他名称

DNA polymerase theta

epididymis secretory sperm binding protein

POLQ 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	POLQ	O75417	RBM25	Homo sapiens	P49756	Anti Tag CoIP	35271311
种属内	POLQ	O75417	RBM25	Homo sapiens	P49756	Crosslink	30021884

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Xeroderma Pigmentosum, Variant Type

Xeroderma Pigmentosum	XPV
Xeroderma Pigmentosum Variant Type	Xeroderma Pigmentosum With Normal Dna Repair Rates
Photosensitivity With Defective Dna Synthesis	Xp
De Sanctis-Cacchione Syndrome	Desanctis-Cacchione Syndrome
Xeroderma Pigmentosa	Xerodermic Idiocy
Xeroderma Pigmentosum Variant	Xp - [Xeroderma Pigmentosum]
Atrophoderma Pigmentosum

Breast Cancer

Breast Carcinoma	Male Breast Cancer
Breast Cancer, Familial	Malignant Neoplasm Of Breast
Breast Cancer, Susceptibility To	Breast Cancer, Early-Onset
Malignant Tumor Of Breast	Carcinoma Of Male Breast
Breast Cancer, Invasive Ductal	Breast Cancer, Protection Against
Breast Cancer, Somatic	Breast Cancer, Male
Breast Cancer, Lobular, Somatic	Breast Tumor
Mammary Cancer	Mammary Tumor
Malignant Neoplasm Of Male Breast	Mammary Carcinoma
Male Breast Carcinoma	Familial Cancer Of Breast
Invasive Ductal Breast Carcinoma	Breast Cancer Susceptibility
Breast Cancer, Male, Susceptibility To	Breast Cancer, Early-Onset, Susceptibility To
Malignant Tumor Of The Breast	Mammary Neoplasm
Primary Breast Cancer	Neoplasm Of Male Breast
Carcinoma Of Breast	Breast Cancer In Men
Familial Breast Cancer	Cancer Of Breast
BC	Breast Cancer Familial
Breast Cancer Familial Male	Breast Cancer, Familial Male
Breast Male Carcinoma	Breast Neoplasms
Breast Neoplasms, Male	Mammary Tumors
Mammary Carcinomas	Cancer, Breast
Cancer, Breast, Susceptibility	Invasive Breast Ductal Carcinoma
Breast Neoplasm	Susceptibility To Breast Cancer
Mammary Neoplasms	Animal Mammary Neoplasms
Primary Malignant Neoplasm Of Breast	Infiltrating Ductal Carcinoma Of Breast
Infiltrating Duct Carcinoma Of Unspecified Site	Infiltrating Ductular Carcinoma Of Unspecified Site
Invasive Breast Carcinoma Of No Special Type	Microinvasive Carcinoma Of Breast
Carcinoma With Apocrine Differentiation

Fanconi Anemia, Complementation Group A

Fanconi Anemia	Fanconi Pancytopenia
Fanconi Anemia Complementation Group A	FANCA
Fa	Fanconi Panmyelopathy
Fanconi'S Anemia	Fanconi Anaemia
Fanconi'S Anaemia	Fanconi Hypoplastic Anemia
Estren-Dameshek Variant Of Fanconi Anemia	Estren-Dameshek Variant Of Fanconi Pancytopenia
Fanconi Anemia Estren-Dameshek Variant	Fanconis Anemia

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS10836	POLQ Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS10833	POLK Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17891	Polq Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS24360	Polq Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	POLQ	VGNC	VGNC:68946
Mus musculus	POLQ	MGD	MGI:2155399
Rattus norvegicus	POLQ	RGD	RGD:1309795
Macaca mulatta	POLQ	VGNC	VGNC:76210
Bos taurus	POLQ	VGNC	VGNC:33130
Others	POLQ	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

POLQ - DNA polymerase theta Gene

关于 POLQ

功能概要

POLQ 基因产物(1)

POLQ 蛋白结构

POLQ 蛋白互作信息

关联疾病

直系同源

热门区域

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POLQ - DNA polymerase theta Gene

关于 POLQ

功能概要

POLQ 基因产物(1)

POLQ 蛋白结构

POLQ 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z