2. Gene
  3. OGFR - opioid growth factor receptor Gene

OGFR - opioid growth factor receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：阿片生长因子受体

种属: Homo sapiens

基因 ID: 11054 | 基因类型: protein coding

关于 OGFR

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,804,835-62,814,000 (from NCBI)

This gene has 3 transcripts (splice variants), 357 orthologues and 1 paralogue. Ubiquitous expression in spleen (RPKM 22.4), lung (RPKM 12.6) and 25 other tissues.

功能概要

该基因编码的蛋白质是阿片样物质生长因子 (OGF) 的受体，也称为 [Met (5) ]-脑啡肽。 OGF 是多种过程中细胞增殖和组织组织的负调节因子。编码的 OGF 未结合受体定位于外核膜，在那里它结合 OGF 并易位到细胞核中。该基因的编码序列包含一个 60 nt 串联不完整重复单元的多态性区域。已经报道了几个包含零到八个重复单元的转录本。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a receptor for opioid growth factor (OGF), also known as [Met(5)]-enkephalin. OGF is a negative regulator of cell proliferation and tissue organization in a variety of processes. The encoded unbound receptor for OGF has been localized to the outer nuclear envelope, where it binds OGF and is translocated into the nucleus. The coding sequence of this gene contains a polymorphic region of 60 nt tandem imperfect repeat units. Several transcripts containing between zero and eight repeat units have been reported. [provided by RefSeq, Jul 2008]

OGFR 基因产物(1)

mRNA Protein Name
NM_007346.4 NP_031372.2 opioid growth factor receptor

OGFR 蛋白结构

OGFr_N

OGFr_N: Opioid growth factor receptor (OGFr) conserved region (84 - 293)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (517 - 536)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (537 - 556)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (557 - 576)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (577 - 596)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (597 - 616)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (617 - 636)

OGFr_III

OGFr_III: Opioid growth factor receptor repeat (637 - 656)

  • 0
  • 200
  • 400
  • 600
  • 677 a.a.
蛋白主名 其他名称

opioid growth factor receptor

protein 7-60

OGFR 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
OGFR Q9NZT2 TERF2IP Homo sapiens Q9NYB0
Pull Down
21044950
种属内
OGFR Q9NZT2 TERF2IP Homo sapiens Q9NYB0
BiFC
21044950
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Keratopathy
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09761 OGFR Human Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus OGFR RGD RGD:69324
Bos taurus OGFR VGNC VGNC:32411
Macaca mulatta OGFR VGNC VGNC:75406
Mus musculus OGFR MGD MGI:1919325
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