CHRNB4 - cholinergic receptor nicotinic beta 4 subunit Gene

中文名称：胆碱能受体烟碱β4 亚单位

种属: Homo sapiens

基因 ID: 1143 | 基因类型: protein coding

关于 CHRNB4

Cytogenetic location: 15q25.1 Genomic coordinates (GRCh38): 15:78,624,111-78,661,641 (from NCBI)

This gene has 6 transcripts (splice variants), 199 orthologues and 45 paralogues. Biased expression in testis (RPKM 1.1), adrenal (RPKM 0.6) and 7 other tissues.

功能概要

该基因存在于一个保守的基因簇中，编码烟碱乙酰胆碱受体 (nAChRs) 超家族的 β 亚基之一，该超家族形成配体门控离子通道，中心孔形成阳离子通道。神经元 nAChR 是五聚体结构，可以是同聚体或异聚体，异聚体结构包含 α 和 β 亚基。每个亚基包含一个胞外氨基末端和四个跨膜结构域。尼古丁是与受体结合的激动剂之一。该基因的变异与尼古丁依赖和肺癌有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2017 年 9 月]

This gene is found within a conserved gene cluster and encodes one of the beta subunits of the nicotinic acetylcholine receptor (nAChRs) superfamily which form ligand-gated ion channels with a central pore that forms a cation channel. Neuronal nAChRs are pentameric structures that can be either homomeric or heteromeric, with heteromeric structures containing both alpha and beta subunits. Each subunit contains an extracellular amino terminus and four transmembrane domains. Nicotine is one of the agonists that binds to the receptor. Variants in this gene have been associated with nicotine dependence and lung Cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2017]

CHRNB4 基因产物(2)

mRNA	Protein	Name
NM_000750.5	NP_000741.1	neuronal acetylcholine receptor subunit beta-4 isoform 1 precursor
NM_001256567.3	NP_001243496.1	neuronal acetylcholine receptor subunit beta-4 isoform 2 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables acetylcholine receptor activity	IDA IDA: 通过直接分析推断	8906617	GOA
enables acetylcholine-gated monoatomic cation-selective channel activity	IDA IDA: 通过直接分析推断	18387948	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	27344019	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in signal transduction	IDA IDA: 通过直接分析推断	8906617	GOA
involved in synaptic transmission involved in micturition	IMP IMP: 通过突变表型推断	11450844	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
part of acetylcholine-gated channel complex	IDA IDA: 通过直接分析推断	8906617	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CHRNB4 蛋白结构

Neur_chan_LBD

Neur_chan_memb

0
100
200
300
400
498 a.a.

蛋白主名

其他名称

neuronal acetylcholine receptor subunit beta-4

acetylcholine receptor, nicotinic, beta 4 (neuronal)

CHRNB4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CHRNB4	P30926	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	CHRNB4	P30926	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	CHRNB4	P30926	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183

种属间: 跨种属相互作用 种属内: 同种属相互作用

CHRNB4 抗体

目录号	产品名	应用	反应物种
HY-P84250	CHRNB4 Antibody (YA3947)	ICC/IF, FC, ELISA	Human

关联疾病

疾病名称

别名

Frontotemporal Dementia

Pallidopontonigral Degeneration	Frontotemporal Lobar Degeneration
Semantic Dementia	FTD
Frontotemporal Lobe Dementia	Multiple System Tauopathy With Presenile Dementia
Dementia, Frontotemporal	Frontotemporal Dementia With Parkinsonism
Mstd	Frontotemporal Lobar Degeneration With Tau Inclusions
Ftld With Tau Inclusions	Dementia, Frontotemporal, With Parkinsonism
Fldem	Ftdp17
Disinhibition-Dementia-Parkinsonism-Amyotrophy Complex	Ddpac
Wilhelmsen-Lynch Disease	Wld
Ppnd	Dementia, Frontotemporal, With Or Without Parkinsonism
Semantic Primary Progressive Aphasia	Semantic Variant Ppa
Wilhemsen-Lynch Disease	Frontotemporal Dementia-Amyotrophic Lateral Sclerosis
Frontotemporal Dementia And Parkinsonism Linked To Chromosome 17	Ftd-Als
Ftld	Pick Complex
Pick Disease Of The Brain	Frontotemporal Dementia With Parkinsonism-17
Grn-Related Frontotemporal Dementia	Frontotemporal Dementia With Motor Neuron Disease
Dementia In Fronto-Temporal Lobar Degeneration	Ftd - [Frontotemporal Dementia]
Temple Dementia	Frontal Lobe Dementia

Tobacco Addiction

Nicotine Dependence	Tobacco Addiction, Susceptibility To
Nicotine Addiction	Tobacco Use Disorder
Smoking Habit	Nicotine Dependence, Protection Against
Nicotine Addiction, Protection From	Cigarette Habituation
Cigarette Habituation, Susceptibility To	Smoking Habit, Susceptibility To
Nicotine Dependence, Susceptibility To	Nicotine Addiction, Susceptibility To
Addiction, Tobacco, Susceptibility To	Compulsive Tobacco User Syndrome
Tobacco Dependence	Tobacco Dependence Syndrome
Cigarette Addiction	Cigarette Dependence
Smoking Addiction	Smokers Syndrome

Substance Dependence

Cocaine Dependence

Autosomal Dominant Nocturnal Frontal Lobe Epilepsy

Adnfle	Autosomal Dominant Sleep-Related Hypermotor Epilepsy
Enfl	Benign Familial Infantile Seizures 6
Benign Familial Infantile Seizures, 6	Nocturnal Frontal Lobe Epilepsy-4
Enfl1	Epilepsy, Nocturnal Frontal Lobe, 1
Epilepsy, Nocturnal Frontal Lobe, Type 1

Lung Cancer

Lung Carcinoma	Non-Small Cell Lung Carcinoma
Lung Cancer, Susceptibility To	Lung Cancer, Protection Against
Adenocarcinoma Of Lung, Somatic	Adenocarcinoma Of Lung, Response To Tyrosine Kinase Inhibitor In
Nonsmall Cell Lung Cancer	Lung Neoplasm
Carcinoma Of Lung	Lung Non-Small Cell Carcinoma
Non-Small Cell Lung Cancer	Nsclc
Lung Neoplasms	Malignant Neoplasm Of Lung
Alveolar Cell Carcinoma	Nonsmall Cell Lung Cancer, Somatic
Nonsmall Cell Lung Cancer, Response To Tyrosine Kinase Inhibitor In	Nonsmall Cell Lung Cancer, Susceptibility To
Lung Cancer, Somatic	Lung Cancer, Resistance To
Cancer Of Lung	Cancer Of Bronchus
Cancer Of The Lung	Lung Malignancies
Lung Malignant Tumors	Malignant Lung Tumor
Malignant Tumor Of Lung	Pulmonary Cancer
Pulmonary Carcinoma	Pulmonary Neoplasms
Respiratory Carcinoma	LNCR
Adenocarcinoma Of Lung	Neoplasm Of Lung
Cancer Lung	Carcinoma Non-Small Cell Lung
Carcinoma, Non-Small-Cell Lung	Lung Cancers
Lung Carcinomas	Cancer, Lung
Cancer, Lung, Non-Small Cell	Primary Malignant Neoplasm Of Lung
Bronchioloalveolar Adenocarcinoma

Drug Dependence

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome 1

Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome	Berdon Syndrome
MMIHS	Megacystis Microcolon Intestinal Hypoperistalsis Syndrome
Megacystis, Microcolon, Hypoperistalsis Syndrome	Visceral Myopathy
Mmih Syndrome	Megacystis-Microcolon-Intestinal Hypoperistalsis-Hydronephrosis Syndrome
MMIHS1	Megacystis-Microcolon-Intestinal Hypoperistalsis Syndrome, Mmih
Mmhs

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02677	CHRNB4 Human Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CHRNB4	MGD	MGI:87892
Rattus norvegicus	CHRNB4	RGD	RGD:2351
Macaca mulatta	CHRNB4	VGNC	VGNC:104701
Felis catus	CHRNB4	VGNC	VGNC:60886
Canis familiaris	CHRNB4	VGNC	VGNC:39245
Bos taurus	CHRNB4	VGNC	VGNC:27333

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CHRNB4 - cholinergic receptor nicotinic beta 4 subunit Gene

关于 CHRNB4

功能概要

CHRNB4 基因产物(2)

CHRNB4 蛋白结构

CHRNB4 蛋白互作信息

CHRNB4 抗体

关联疾病

直系同源

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CHRNB4 - cholinergic receptor nicotinic beta 4 subunit Gene

关于 CHRNB4

功能概要

CHRNB4 基因产物(2)

CHRNB4 蛋白结构

CHRNB4 蛋白互作信息

CHRNB4 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z