CKB - creatine kinase B Gene

中文名称：肌酸激酶 B

种属: Homo sapiens

同用名: BCK; B-CK; CKBB; CPK-B; HEL-211; HEL-S-29

基因 ID: 1152 | 基因类型: protein coding

关于 CKB

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,519,667-103,522,830 (from NCBI)

This gene has 18 transcripts (splice variants), 214 orthologues and 4 paralogues. Broad expression in colon (RPKM 268.3), prostate (RPKM 227.9) and 18 other tissues.

功能概要

该基因编码的蛋白质是一种参与能量稳态的细胞质酶。编码的蛋白质可逆地催化磷酸盐在 ATP 和各种磷原 (如磷酸肌酸) 之间的转移。它在大脑和其他组织中充当同二聚体，在心脏中充当具有相似肌肉同工酶的异二聚体。编码的蛋白质是 ATP:胍基磷酸转移酶蛋白质家族的成员。该基因的假基因已被表征。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a cytoplasmic enzyme involved in energy homeostasis. The encoded protein reversibly catalyzes the transfer of phosphate between ATP and various phosphogens such as creatine phosphate. It acts as a homodimer in brain as well as in Other tissues, and as a heterodimer with a similar muscle isozyme in heart. The encoded protein is a member of the ATP:guanido phosphotransferase protein family. A pseudogene of this gene has been characterized. [provided by RefSeq, Jul 2008]

CKB 基因产物(2)

mRNA	Protein	Name
NM_001362531.2	NP_001349460.1	creatine kinase B-type isoform 2
NM_001823.5	NP_001814.2	creatine kinase B-type isoform 1

基因本体论

分子功能
生物过程

分子功能 GO 注释	逻辑证据	参考文献	来源
enables creatine kinase activity	IDA IDA: 通过直接分析推断	8186255	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	16189514	GOA
enables ubiquitin protein ligase binding	IPI IPI: 通过物理相互作用推断	19725078	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in phosphocreatine biosynthetic process	IDA IDA: 通过直接分析推断	8186255	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CKB 蛋白结构

ATP-gua_PtransN

ATP-gua_Ptrans

0
100
200
300
381 a.a.

蛋白主名

其他名称

creatine kinase B-type

brain creatine kinase

CKB 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CKB	P12277	CKM	Homo sapiens	P06732	Anti Tag CoIP	35271311
种属内	CKB	P12277	CKM	Homo sapiens	P06732	Anti Tag CoIP	33961781
种属内	CKB	P12277	CKM	Homo sapiens	P06732	Anti Tag CoIP	28514442
种属内	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Y2H Pooling	16189514
种属内	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Validated Y2H	32296183
种属内	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Y2H Prey Pooling	25416956
种属内	CKB	P12277	ASB9	Homo sapiens	Q96DX5	Validated Y2H	25416956
种属间	CKB	P12277	Q03463-PRO_0000278738	Hepatitis C virus	Q03463-PRO_0000278738	Anti Tag CoIP	19264780

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CKB 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7897	Creatine kinase B-type/CKB Protein, Human (His)	P12277 (M1-K381)	≥95%

CKB 抗体

目录号	产品名	应用	反应物种
HY-P80629	Creatine Kinase B type Antibody (YA492)	WB, IHC-P, IP	Human, Mouse, Rat

关联疾病

疾病名称

别名

Subendocardial Myocardial Infarction

Neonatal Hypoxic And Ischemic Brain Injury

Perinatal Asphyxia	Hypoxic-Ischemic Encephalopathy
Perinatal Hypoxia	Hie
Hypoxic And Ischemic Brain Injury In The Newborn	Encephalopathy, Hypoxic Ischemic
Encephalopathies Hypoxic-Ischemic	Hypoxic Ischemic Encephalopathy
Hypoxic Ischaemic Brain Injury	Brain Hypoxia
Cerebral Hypoxia	Hypoxic Encephalopathy
Hypoxic Brain Damage	Hypoxic Brain Injury
Brainstem Hypoxia	Hypoxic Brainstem Damage

Acute Myocardial Infarction

Cardiac Attack

Heart Attack

Cardiac Arrest

Cardiopulmonary Arrest	Circulatory Arrest
Heart Arrest

Bacterial Meningitis

Meningitis, Bacterial	Meningitis Bacterial
Bm - [Bacterial Meningitis]	Leptomeningitis Bacterial
Pachymeningitis Bacterial	Arachnoiditis Bacterial

Prostate Rhabdomyosarcoma

Rhabdomyosarcoma Of The Prostate

Myocardial Infarction

Heart Attack	Myocardial Infarction, Susceptibility To
Myocardial Infarction 1	Myocardial Infarction, Protection Against
Myocardial Infarction, Decreased Susceptibility To	Myocardial Infarction, Decreased
Myocardial Infarct	MCI1
Premature Myocardial Infarction	Myocardial Infarction, Susceptibility To, Type 1

Small Cell Cancer Of The Lung

Small Cell Lung Cancer	Small Cell Lung Carcinoma
Sclc	Small-Cell Cancer Of Lung
Lung Small Cell Carcinoma	Sclc1
Sccl	Cancer, Lung, Small Cell
Small Cell Carcinoma Of Lung	Carcinoma, Small Cell

Mitral Valve Insufficiency

Mitral Regurgitation	Congenital Insufficiency Of Mitral Valve
Congenital Mitral Insufficiency	Congenital Mitral Regurgitation
Mitral Valve Incompetence	Mitral Valve Regurgitation
Mr - [Mitral Regurgitation]	Mi - [Mitral Incompetence]
Mitral Valve Annular Incompetency	Congenital Mitral Valve Incompetence
Congenital Mitral Valve Insufficiency	Congenital Mitral Valve Regurgitation
Congenital Mitral Incompetence

Osteopetrosis

Marble Bone Disease	Albers-Schonberg Disease
Osteopetroses	Marble Bones
Osteopetrosis And Related Disorders	Congenital Osteopetrosis
Marble Bone	Albers-Schoenberg Disease
Albers-Schonberg Osteopetrosis	Osteosclerosis Fragilis
Ivory Bones

Huntington Disease

Huntington'S Disease	Huntington Chorea
Huntington'S Chorea	HD
Huntington Chronic Progressive Hereditary Chorea	Juvenile Huntington Disease
Chronic Progressive Chorea	Chronic Progressive Hereditary Chorea
Hc - [Huntington Chorea]	Hereditary Chorea
Progressive Hereditary Chorea

Heart Disease

Heart Failure	Congenital Heart Disease
Heart Diseases	Congenital Heart Defects
Congenital Heart Defect	Heart Malformation
Congenital Anomaly Of Heart	Heart Defect
Heart-Congenital Defect	Congenital Heart Disorder
Heart Defects Congenital	Heart Defects, Congenital
Heart Defects	Heart Disease, Congenital
Disease, Heart, Congenital	Congestive Heart Failure

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS02634	CHKB Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS02736	CKB Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS17439	Ckb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS22118	Chkb Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23895	Ckb Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

直系同源

种属	基因名	来源	基因 ID
Macaca mulatta	CKB	VGNC	VGNC:108291
Mus musculus	CKB	MGD	MGI:88407
Bos taurus	CKB	VGNC	VGNC:27384
Rattus norvegicus	CKB	RGD	RGD:2357
Felis catus	CKB	VGNC	VGNC:60913
Macaca fascicularis	CKB	NCBI	NCBI:102121556
Others	CKB	NCBI

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CKB - creatine kinase B Gene

关于 CKB

功能概要

CKB 基因产物(2)

CKB 蛋白结构

CKB 蛋白互作信息

重组 CKB 蛋白

CKB 抗体

关联疾病

直系同源

热门区域

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CKB - creatine kinase B Gene

关于 CKB

功能概要

CKB 基因产物(2)

CKB 蛋白结构

CKB 蛋白互作信息

重组 CKB 蛋白

CKB 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z