2. Gene
  3. Adrb2 - adrenergic receptor, beta 2 Gene

Adrb2 - adrenergic receptor, beta 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Badm; Gpcr7; Adrb-2

基因 ID: 11555 | 基因类型: protein coding

关于 Adrb2

功能概要

This intronless gene belongs to the G-protein-coupled receptor superfamily, which includes transmembrane proteins that play a role in signal transduction across biological membranes resulting in a variety of physiological responses. The encoded protein is a beta-2 Adrenergic Receptor which is activated by Catecholamine ligands such as adrenaline and epinephrine. The protein participates in the classical signaling pathway involving G protein, adenylyl cyclase, cAMP (3'-5'-cyclic adenosine monophosphate) and protein kinase A (PKA). In humans, this gene is implicated in susceptibility to nocturnal asthma, obesity and type 2 diabetes. [provided by RefSeq, Apr 2013]

Adrb2 基因产物(1)

mRNA Protein Name
NM_007420.3 NP_031446.2 beta-2 adrenergic receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables adenylate cyclase binding IDA
IDA: 通过直接分析推断
12297500 MGI
enables beta2-adrenergic receptor activity IDA
IDA: 通过直接分析推断
2834198 MGI
enables enzyme binding IPI
IPI: 通过物理相互作用推断
19801680 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9235896 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
2834198 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
15724149 MGI
acts upstream of or within bone resorption IMP
IMP: 通过突变表型推断
15724149 MGI
acts upstream of or within brown fat cell differentiation IGI
IGI: 通过遗传相互作用推断
12387862 MGI
involved in cellular response to amyloid-beta IGI
IGI: 通过遗传相互作用推断
20395454 MGI
acts upstream of or within diet induced thermogenesis IGI
IGI: 通过遗传相互作用推断
12161655 MGI
acts upstream of or within heat generation IGI
IGI: 通过遗传相互作用推断
12161655 MGI
acts upstream of or within negative regulation of multicellular organism growth IGI
IGI: 通过遗传相互作用推断
12387862 MGI
acts upstream of or within negative regulation of smooth muscle contraction IGI
IGI: 通过遗传相互作用推断
12925702 MGI
acts upstream of or within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IGI
IGI: 通过遗传相互作用推断
10358009 MGI
acts upstream of or within norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure IMP
IMP: 通过突变表型推断
10358009 MGI
acts upstream of or within positive regulation of bone mineralization IMP
IMP: 通过突变表型推断
15724149 MGI
involved in positive regulation of cAMP/PKA signal transduction IGI
IGI: 通过遗传相互作用推断
20395454 MGI
involved in positive regulation of cold-induced thermogenesis IGI
IGI: 通过遗传相互作用推断
12387862 MGI
involved in positive regulation of mini excitatory postsynaptic potential IGI
IGI: 通过遗传相互作用推断
20395454 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15724149 MGI
acts upstream of or within regulation of sodium ion transport IMP
IMP: 通过突变表型推断
15016730 MGI
acts upstream of or within regulation of systemic arterial blood pressure by norepinephrine-epinephrine IMP
IMP: 通过突变表型推断
10358008 MGI
acts upstream of or within response to cold IGI
IGI: 通过遗传相互作用推断
12161655 MGI
acts upstream of smooth muscle contraction IGI
IGI: 通过遗传相互作用推断
12925702 MGI
acts upstream of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
15724149 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
14625387 MGI
located in membrane IDA
IDA: 通过直接分析推断
2834198 MGI
is active in neuronal dense core vesicle EXP
EXP: 通过实验结果推断
21321602 MGI
is active in neuronal dense core vesicle IDA
IDA: 通过直接分析推断
21321602 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15791602 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

beta-2 adrenergic receptor

beta 2-AR

beta-2 adrenoceptor

beta-2 adrenoreceptor

相关产品

Approval
生物活性分子 (2)
目录号 产品名 作用方式
纯度 是否罕见病
HY-14299 Indacaterol Agonist 99.98% 否
HY-14299A Indacaterol maleate Agonist 99.82% 否
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-14299D Indacaterol acetate Agonist / Phase 4
Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13338 Mabuterol Agonist 99.96% 否
HY-RS00415 ADRB2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-14299B (S)-Indacaterol / 否
HY-152051S Mabuterol-d9 hydrochloride Agonist / 否
HY-RS16956 Adrb2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23399 Adrb2 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-W755295 Mabuterol hydrochloride Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adrb2 NCBI NCBI:154
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