2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Mabuterol hydrochloride

Mabuterol hydrochloride 是一种选择性和具有口服活性的 β-2 肾上腺素能受体 (ADRB2) 激动剂。Mabuterol hydrochloride 抑制抑制 PDGF-BB 诱导的细胞增殖和细胞内 Ca2+ 增加。Mabuterol hydrochloride 抑制 PDGF-BB 诱导的 Drp-1、cyclinD1 和 PCNA 蛋白表达，并增强 Mfn-2 表达。

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Mabuterol hydrochloride Chemical Structure

Mabuterol hydrochloride Chemical Structure

CAS No. : 54240-36-7

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Other Forms of Mabuterol hydrochloride:

Mabuterol hydrochloride 相关抗体

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α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Mabuterol hydrochloride is a selective and orally active beta-2 adrenergic receptor (ADRB2) agonist. Mabuterol hydrochloride inhibits the proliferation and suppresses the increase of intracellular Ca2+ induced by PDGF-BB. Mabuterol hydrochloride suppresses the protein expressions of Drp-1, cyclinD1 and PCNA and enhanced the expression of Mfn-2 induced by PDGF-BB[1][2].

IC50 & Target[1]

Beta-2 adrenergic receptor

 

体外研究
(In Vitro)

Mabuterol hydrochloride (10-60 µM; 48 h) 抑制 PDGF-BB 诱导的 ASMC 增殖[2]。
Mabuterol hydrochloride (50 µM; 1h) 抑制 PDGF-BB (25ng/ml) 诱导的细胞内 Ca2+ 增加[2]。
Mabuterol hydrochloride(50 µM; 48 h) 显着抑制 PDGF-BB 诱导的 Drp-1、cyclinD1 和 PCNA 蛋白表达，并增强 Mfn-2 表达[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Mabuterol hydrochloride 相关抗体:

Cell Viability Assay[2]

Cell Line: rat ASMCs
Concentration: 10, 20, 30, 40, 50, 60 µM
Incubation Time: 24, 48 h
Result: Inhibited the proliferation of ASMCs induced by PDGF-BB (25 ng/ml) in a dose-dependent maner at 48 h.
分子量

347.20

Formula

C13H19Cl2F3N2O
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Mabuterol hydrochloride 相关分类

  • 摩尔计算器

  • 稀释计算器

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mabuterol54240-36-7Adrenergic ReceptorBeta ReceptorASMCsDrp-1cyclinD1PCNAPDGF-BBMfn-2Ca2+Inhibitorinhibitorinhibit

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目录号：
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