2. Gene
  3. Tirap - toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Gene

Tirap - toll-interleukin 1 receptor (TIR) domain-containing adaptor protein Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Mal; Wyatt; Tlr4ap; C130027E04Rik

基因 ID: 117149 | 基因类型: protein coding

关于 Tirap

功能概要

Enables Toll-like Receptor 2 binding activity; identical protein binding activity; and phosphatidylinositol-4,5-bisphosphate binding activity. Involved in several processes, including positive regulation of B cell proliferation; positive regulation of NF-kappaB transcription factor activity; and regulation of cytokine production. Acts upstream of or within several processes, including I-kappaB kinase/NF-kappaB signaling; myeloid cell differentiation; and response to bacterium. Located in endocytic vesicle and ruffle membrane. Is expressed in testis. Human ortholog(s) of this gene implicated in malaria and tuberculosis. Orthologous to human TIRAP (TIR domain containing adaptor protein). [provided by Alliance of Genome Resources, Apr 2022]

Tirap 基因产物(4)

mRNA Protein Name
NM_001177845.1 NP_001171316.1 toll/interleukin-1 receptor domain-containing adapter protein
NM_001177846.1 NP_001171317.1 toll/interleukin-1 receptor domain-containing adapter protein
NM_001177847.1 NP_001171318.1 toll/interleukin-1 receptor domain-containing adapter protein
NM_054096.2 NP_473437.2 toll/interleukin-1 receptor domain-containing adapter protein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables Toll-like receptor 2 binding IPI
IPI: 通过物理相互作用推断
17322885 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
11544529 MGI
enables phosphatidylinositol-4,5-bisphosphate binding IDA
IDA: 通过直接分析推断
16751103 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11544529 MGI
enables signaling adaptor activity IMP
IMP: 通过突变表型推断
11526399 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cell surface receptor signaling pathway IPI
IPI: 通过物理相互作用推断
11526399 MGI
acts upstream of or within cellular response to bacterial lipopeptide IMP
IMP: 通过突变表型推断
15690042 MGI
acts upstream of or within cellular response to lipoteichoic acid IMP
IMP: 通过突变表型推断
15690042 MGI
acts upstream of or within defense response to Gram-positive bacterium IMP
IMP: 通过突变表型推断
15690042 MGI
NOT involved in interleukin-1-mediated signaling pathway IDA
IDA: 通过直接分析推断
11544529 MGI
acts upstream of macrophage cytokine production IMP
IMP: 通过突变表型推断
15690042 MGI
acts upstream of or within myeloid cell differentiation IMP
IMP: 通过突变表型推断
11526399 MGI
involved in positive regulation of B cell proliferation IMP
IMP: 通过突变表型推断
12447442 MGI
involved in positive regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
12447442 MGI
involved in positive regulation of canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
11526399 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 1 production IMP
IMP: 通过突变表型推断
16301656 MGI
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: 通过突变表型推断
16301656 MGI
involved in positive regulation of innate immune response IMP
IMP: 通过突变表型推断
16301656 MGI
involved in positive regulation of interleukin-12 production IMP
IMP: 通过突变表型推断
12447442 MGI
involved in positive regulation of interleukin-6 production IDA
IDA: 通过直接分析推断
12421970 MGI
involved in positive regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
12447442 MGI
involved in positive regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
16301656 MGI
acts upstream of or within positive regulation of macrophage cytokine production IMP
IMP: 通过突变表型推断
15690042 MGI
involved in positive regulation of neutrophil chemotaxis IMP
IMP: 通过突变表型推断
18039275 MGI
involved in positive regulation of toll-like receptor 3 signaling pathway IDA
IDA: 通过直接分析推断
17322885 MGI
acts upstream of or within positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
15690042 MGI
involved in positive regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
12447442 MGI
involved in regulation of interferon-beta production IDA
IDA: 通过直接分析推断
14630816 MGI
involved in regulation of interleukin-15 production IMP
IMP: 通过突变表型推断
18583567 MGI
involved in toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
11526399 MGI
NOT involved in toll-like receptor 5 signaling pathway IMP
IMP: 通过突变表型推断
12447442 MGI
acts upstream of tumor necrosis factor production IMP
IMP: 通过突变表型推断
15690042 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in endocytic vesicle IDA
IDA: 通过直接分析推断
16751103 MGI
NOT located in peroxisome IDA
IDA: 通过直接分析推断
20451243 MGI
located in ruffle membrane IDA
IDA: 通过直接分析推断
16751103 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

toll/interleukin-1 receptor domain-containing adapter protein

TIR domain-containing adapter protein

Toll-like receptor 4 adaptor protein

adaptor protein Wyatt

myD88 adapter-like protein

Tirap 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Tirap Q99JY1 Pik3ap1 Mus musculus Q9EQ32
Anti Tag CoIP
22187460
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS14551 TIRAP Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS19486 Tirap Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25980 Tirap Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tirap NCBI NCBI:114609
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