Rhoa - ras homolog family member A Gene

种属: Rattus norvegicus

同用名: Arha; Arha2

基因 ID: 117273 | 基因类型: protein coding

关于 Rhoa

功能概要

Enables several functions, including GTPase activity; Rho GDP-dissociation inhibitor binding activity; and guanyl ribonucleotide binding activity. Involved in several processes, including intracellular signal transduction; positive regulation of cellular protein metabolic process; and regulation of neuron projection development. Acts upstream of or within negative regulation of vascular associated smooth muscle cell migration and negative regulation of vascular associated smooth muscle cell proliferation. Located in axon; cytosol; and membrane. Used to study membranous glomerulonephritis. Biomarker of asthma; fetal alcohol syndrome; hypertension; obesity; and pulmonary hypertension. Human ortholog(s) of this gene implicated in breast carcinoma. Orthologous to human RHOA (Ras homolog family member A). [provided by Alliance of Genome Resources, Apr 2022]

Rhoa 基因产物(1)

mRNA	Protein	Name
NM_057132.3	NP_476473.1	transforming protein RhoA

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables GDP binding	IDA IDA: 通过直接分析推断	20472934	RGD
enables GTP binding	IDA IDA: 通过直接分析推断	20472934	RGD
enables GTPase activity	IDA IDA: 通过直接分析推断	21440892	RGD
enables Rho GDP-dissociation inhibitor binding	IPI IPI: 通过物理相互作用推断	17379756	RGD
enables protein binding	IPI IPI: 通过物理相互作用推断	17620967	RGD
enables protein domain specific binding	IPI IPI: 通过物理相互作用推断	11696353	RGD

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in GTP metabolic process	IDA IDA: 通过直接分析推断	21440892	RGD
acts upstream of or within Rho protein signal transduction	IMP IMP: 通过突变表型推断	29453251	RGD
involved in microtubule depolymerization	IMP IMP: 通过突变表型推断	20858895	RGD
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: 通过突变表型推断	17615156	RGD
involved in negative regulation of neuron differentiation	IMP IMP: 通过突变表型推断	14517206	RGD
involved in negative regulation of neuron projection development	IGI IGI: 通过遗传相互作用推断	14662747	RGD
involved in negative regulation of synapse assembly	IMP IMP: 通过突变表型推断	27893610	RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell migration	IMP IMP: 通过突变表型推断	29453251	RGD
acts upstream of or within negative regulation of vascular associated smooth muscle cell proliferation	IMP IMP: 通过突变表型推断	29453251	RGD
involved in neuron projection morphogenesis	IEP IEP: 通过表达模式推断	17109064	RGD
involved in positive regulation of actin filament polymerization	IMP IMP: 通过突变表型推断	17369454	RGD
involved in positive regulation of cell adhesion	IEP IEP: 通过表达模式推断	17488779	RGD
involved in positive regulation of cell growth	IEP IEP: 通过表达模式推断	17562852	RGD
involved in positive regulation of cell growth	IMP IMP: 通过突变表型推断	17537920	RGD
involved in positive regulation of cell migration	IEP IEP: 通过表达模式推断	17488779	RGD
involved in positive regulation of cysteine-type endopeptidase activity involved in apoptotic process	IMP IMP: 通过突变表型推断	17425560	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: 通过突变表型推断	17425560	RGD
involved in positive regulation of smooth muscle contraction	IMP IMP: 通过突变表型推断	17379756	RGD
involved in positive regulation of translation	IEP IEP: 通过表达模式推断	17562852	RGD
involved in positive regulation of vasoconstriction	IEP IEP: 通过表达模式推断	17468135	RGD
involved in regulation of actin polymerization or depolymerization	IEP IEP: 通过表达模式推断	17562852	RGD
involved in regulation of calcium ion transport	IMP IMP: 通过突变表型推断	17558400	RGD
involved in regulation of dendrite development	IMP IMP: 通过突变表型推断	17670984	RGD
involved in response to amino acid	IEP IEP: 通过表达模式推断	17515837	RGD
involved in response to ethanol	IEP IEP: 通过表达模式推断	17109064	RGD
involved in response to glucocorticoid	IEP IEP: 通过表达模式推断	18391481	RGD
involved in response to glucose	IEP IEP: 通过表达模式推断	18356410	RGD
involved in response to hypoxia	IEP IEP: 通过表达模式推断	16205723	RGD
involved in response to mechanical stimulus	IEP IEP: 通过表达模式推断	17456553	RGD
involved in response to xenobiotic stimulus	IDA IDA: 通过直接分析推断	17492663	RGD
involved in response to xenobiotic stimulus	IEP IEP: 通过表达模式推断	17596891	RGD
involved in stress-activated protein kinase signaling cascade	IMP IMP: 通过突变表型推断	17369826	RGD

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in axon	IDA IDA: 通过直接分析推断	18554585	RGD
located in cytosol	IDA IDA: 通过直接分析推断	21440892	RGD
located in dendrite	IDA IDA: 通过直接分析推断	26738857	RGD
located in dendritic spine	IDA IDA: 通过直接分析推断	26738857	RGD
located in membrane	IDA IDA: 通过直接分析推断	21440892	RGD
located in neuronal cell body	IDA IDA: 通过直接分析推断	26738857	RGD

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

transforming protein RhoA

plysia ras-related homolog A2

ras homolog gene family, member A

相关产品

Approval

生物活性分子 (5)

目录号	产品名	纯度	是否罕见病
HY-10341	Fasudil Hydrochloride	99.97%	是
HY-109523	Cerivastatin sodium	99.89%	否
HY-10341A	Fasudil	99.91%	是
HY-10341C	Fasudil dihydrochloride	99.98%	是
HY-10341B	Fasudil hydrochloride semihydrate	/	否

Clinical Phase

生物活性分子 (1)

目录号	产品名	作用方式	纯度	Phase
HY-I0400	N-Acetylneuraminic acid		99.90%	Phase 1

Pre-clinical Phase

生物活性分子 (30)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12646	Rhosin hydrochloride		99.94%	否
HY-108566	U-46619	Agonist	≥99.0%	否
HY-16563	Narciclasine	Activator	99.88%	否
HY-15477	YS-49		99.80%	否
HY-108361	CCG-203971	Inhibitor	99.89%	否
HY-115376	Z62954982	Inhibitor	99.38%	否
HY-12649	Y16	Inhibitor	98.10%	否
HY-135457	JMS-053	Inhibitor	98.0%	否
HY-12646A	Rhosin		95.08%	否
HY-113849	MLS-573151	Inhibitor	99.70%	否
HY-117548	UNC1062		98.92%	否
HY-15477A	YS-49 monohydrate		99.71%	否
HY-145915A	(E/Z)-ZINC09659342	Inhibitor	99.71%	否
HY-168596	RhoA-ROCK-IN-1		/	否
HY-P2325	Exoenzyme C3, clostridium botulinum	Inhibitor	/	否
HY-RS11945	RHOA Human Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-109523S	Cerivastatin-d3 sodium		/	否
HY-129458	Cerivastatin		/	否
HY-139061	Palmitoyl 3-carbacyclic phosphatidic acid	Inhibitor	/	否
HY-145915	ZINC09659342	Inhibitor	/	否
HY-162968	MRTF-A-IN-1	Inhibitor	/	否
HY-162969	MRTF-A-IN-2	Inhibitor	/	否
HY-172917	Rho GTPase inhibitor 1	Inhibitor	/	否
HY-176267	AH001	Inhibitor	/	否
HY-10341D	Fasudil mesylate		/	否
HY-121667	Scaff10-8	Inhibitor	/	否
HY-158652	(R)-CCG-1423	Inhibitor	/	否
HY-N14739	Dykellic acid	Inhibitor	/	否
HY-RS17004	Rhoa Mouse Pre-designed siRNA Set A	Pre-designed Set	/	否
HY-RS23447	Rhoa Rat Pre-designed siRNA Set A	Pre-designed Set	/	否

抗体抑制剂 (1)

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-P990805	Anti-Human/Mouse GRP78 Antibody (C38)	Inhibitor	95.00%	否

直系同源

种属	基因名	来源	基因 ID
Homo sapiens	Rhoa	NCBI	NCBI:387

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