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  4. Exoenzyme C3, clostridium botulinum

Exoenzyme C3, clostridium botulinum  (Synonyms: 胞外酶C3，来源于肉毒梭菌)

目录号: HY-P2325
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Exoenzyme C3, clostridium botulinum 是一种单 ADP 核糖基化酶。ADP-ribosyltransferase 通过将 ADP-核糖转移到 RhoA、B 和 C 上，特异性地修饰 RhoA、B 和 C，从而使这些 GTP 酶失活。Exoenzyme C3, clostridium botulinum 可诱导神经元轴突和树突生长，抑制巨噬细胞迁移，并调节细胞骨架动态。Exoenzyme C3, clostridium botulinum 可用于脊髓损伤和糖尿病痛性神经病变的研究。

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Exoenzyme C3, clostridium botulinum

Exoenzyme C3, clostridium botulinum Chemical Structure

CAS No. : 58319-92-9

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25 μg ￥13650
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Exoenzyme C3, clostridium botulinum 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Exoenzyme C3, clostridium botulinum, is a mono-ADP-ribosylating enzyme. Exoenzyme C3, clostridium botulinum specifically modifies RhoA, B, and C by transferring ADP-ribose to them, thereby inactivating these GTPases. Exoenzyme C3, clostridium botulinum can induce neuronal axonal and dendritic growth, inhibit macrophage migration, and regulate cytoskeletal dynamics. Exoenzyme C3, clostridium botulinum can be used in the research of spinal cord injury and diabetic painful neuropathy[1][2][3][4][5].

体外研究
(In Vitro)

Exoenzyme C3, Clostridium botulinum (10 nM-1 μM；7-24 h) 通过 RhoA ADP-核糖基化诱导 J774A.1 巨噬细胞出现双极突起[2]。
Exoenzyme C3, Clostridium botulinum (1 μM；72 h) 改变 SH-SY5Y 细胞中 55 种蛋白质的丰度[3]。
Exoenzyme C3, Clostridium botulinum (1 μM；24-144 h) 导致 HT22 细胞发生显著蛋白质组变化[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Exoenzyme C3, clostridium botulinum 相关抗体:
体内研究
(In Vivo)

Exoenzyme C3, Clostridium botulinum (1-10 pg；鞘内注射) 可剂量依赖性地延长糖尿病小鼠的甩尾潜伏期并提高其机械阈值[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal and Streptozotocin (HY-13753)-induced diabetic male ICR mice (weighing about 20 g) aged 4 weeks[5]
Dosage: 1 pg, 3 pg, 10 pg
Administration: Intrathecal injection
Result: Dose-dependently prolonged the tail-flick latency of diabetic mice at 24, 48 and 72 h after treatment and increased their mechanical threshold at 48 h after treatment.
Had no effect on the tail-flick latency and mechanical threshold of non-diabetic mice.
CAS 号
性状

固体

颜色

White to off-white

中文名称

胞外酶C3，来源于肉毒梭菌
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Exoenzyme C3, clostridium botulinum 相关分类

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Keywords:

Exoenzyme C3, clostridium botulinum58319-92-9胞外酶C3，来源于肉毒梭菌Biochemical Assay ReagentsROCKRho-associated protein kinaseRho-associated kinaseRho-kinaseROKGrowth coneNeuroneNeuronal injuryRhoneuro-regenerationpost-traumaticInhibitorinhibitorinhibit

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