2. Cell Cycle/DNA Damage Metabolic Enzyme/Protease
  3. HSP
  4. Anti-Human/Mouse GRP78 Antibody (C38)

Anti-Human/Mouse GRP78 Antibody (C38) 

目录号: HY-P990805 纯度: 95.00%
COA 技术支持

Anti-Human/Mouse GRP78 Antibody (C38) 是一种小鼠 IgG2b 抗体抑制剂，靶向 GRP78。Anti-Human/Mouse GRP78 Antibody (C38) 抑制 RhoA、ROCK 和 AKT 的激活。Anti-Human/Mouse GRP78 Antibody (C38) 可用于癌症和代谢性疾病的研究，如黑色素瘤和糖尿病。

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Anti-Human/Mouse GRP78 Antibody (C38)

Anti-Human/Mouse GRP78 Antibody (C38) Chemical Structure

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3.  试用装只面向终端客户。

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Anti-Human/Mouse GRP78 Antibody (C38) 相关抗体

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HSP40 HSP70 HSP90 HSP105 HSF1 HSP HSPA5

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Anti-Human/Mouse GRP78 Antibody (C38) is a kind of mouse IgG2b antibody inhibitor, targeting to GRP78. Anti-Human/Mouse GRP78 Antibody (C38) inhibits RhoA, ROCK and AKT activation. Anti-Human/Mouse GRP78 Antibody (C38) can be used for the researches of cancer and metabolic disease, such as melanoma and diabetes[1][2].

同型

Mouse IgG2b kappa
推荐同型对照抗体
反应种属

Human/Mouse
IC50 & Target

GRP78
体外研究
(In Vitro)

Anti-Human/Mouse GRP78 Antibody (C38) (2 μg) 可抑制高糖诱导的系膜细胞中 RhoA 和 ROCK 的激活[1]。
Anti-Human/Mouse GRP78 Antibody (C38) (30 mins) 可完全消除 B16F1 黑色素瘤细胞中 Akt 的激活[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Mouse GRP78 Antibody (C38) 相关抗体:
体内研究
(In Vivo)

Anti-Human/Mouse GRP78 Antibody (C38) (初始剂量 200 μg，随后 12 周每周 100 μg，腹腔注射) 可减弱 1 型糖尿病小鼠模型中糖尿病肾脏的 RhoA 激活[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Type 1 diabetes mice models[1]
Dosage: 200 μg at an initial dose and 100 µg weekly for 12 weeks
Administration: Intraperitoneally injection
Result: Attenuated RhoA activation in diabetic kidneys.
基因 ID

14828  [NCBI]

Accession
应用

ELISA, FACS, Functional assay, Research in vivo
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

150 kDa

性状

液体

颜色

Colorless to light yellow

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 95.00%

COA (268 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Anti-Human/Mouse GRP78 Antibody (C38) 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Human/Mouse GRP78 Antibody (C38)HSPHeat shock proteinsGRP78RhoAROCKAKTCancerMelanomaDiabetesInhibitorinhibitorinhibit

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