2. Gene
  3. CLPS - colipase Gene

CLPS - colipase Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：脂肪酶

种属: Homo sapiens

基因 ID: 1208 | 基因类型: protein coding

关于 CLPS

Cytogenetic location: 6p21.31 Genomic coordinates (GRCh38): 6:35,794,982-35,797,323 (from NCBI)

This gene has 3 transcripts (splice variants), 135 orthologues and 3 paralogues. Restricted expression toward pancreas (RPKM 17741.6).

功能概要

该基因编码的蛋白质是胰脂肪酶有效水解膳食脂质所需的辅助因子。它与脂肪酶的 C 端非催化结构域结合，从而稳定活性构象并显着增加整体疏水结合位点。该基因产物允许脂肪酶非共价锚定在脂质胶束表面，抵消肠道胆盐的不稳定影响。该辅助因子仅在胰腺腺泡细胞中表达，表明组织特异性元件对表达进行调节。已发现该基因的三个转录变体编码不同的亚型。[RefSeq 提供，2011 年 11 月]

The protein encoded by this gene is a cofactor needed by pancreatic Lipase for efficient dietary lipid hydrolysis. It binds to the C-terminal, non-catalytic domain of Lipase, thereby stabilizing an active conformation and considerably increasing the overall hydrophobic binding site. The gene product allows Lipase to anchor noncovalently to the surface of lipid micelles, counteracting the destabilizing influence of intestinal bile salts. This cofactor is only expressed in pancreatic acinar cells, suggesting regulation of expression by tissue-specific elements. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

CLPS 基因产物(3)

mRNA Protein Name
NM_001252597.2 NP_001239526.1 colipase isoform 2
NM_001252598.2 NP_001239527.1 colipase isoform 3 preproprotein
NM_001832.4 NP_001823.1 colipase isoform 1 preproprotein

CLPS 蛋白结构

Colipase

Colipase: Colipase, N-terminal domain (21 - 60)

Colipase_C

Colipase_C: Colipase, C-terminal domain (62 - 106)

  • 0
  • 100
  • 112 a.a.
蛋白主名 其他名称

colipase

colipase, pancreatic

重组 CLPS 蛋白

目录号 产品名 蛋白编号 纯度
HY-P72933 CLPS Protein, Human (sf9, His) P04118 (A18-Q112) ≥95%

关联疾病

疾病名称 别名
Pancreas Disease

Abnormality Of The Pancreas

Pancreatic Diseases
Acute Pancreatitis

Pancreatitis

Pancreatitis, Acute Necrotizing

Pancreatitis Nos

Acute Pancreas Inflammation
Pancreatic Steatorrhea

Pancreatic Steatorrhoea

Decreased Tolerance Of Pancreas

Pancreatic Disturbance Of Fat Absorption
Johanson-Blizzard Syndrome

JBS

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia, And Congenital Deafness

Nasal Alar Hypoplasia, Hypothyroidism, Pancreatic Achylia And Congenital Deafness

Johanson Blizzard Syndrome
Keratomalacia

Vitamin A Deficiency

Night Blindness

Retinol Deficiency

Xerotic Keratitis

VAD

Vitamin A

Hypovitaminosis A

Bitot Spots

Bitot Spots In The Young Child

Conjunctival Xerosis With Bitot'S Spots

Vitamin A Deficiency With Cornea Xerosis

Vitamin A Deficiency With Cornea Ulceration Or Xerosis
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Cone-Rod Dystrophy 2

Cone-Rod Dystrophy

CORD2

Cone-Rod Retinal Dystrophy

Rcrd2

Cone-Rod Retinal Dystrophy 2

Crd2

Cord

Crd

Retinal Cone-Rod Dystrophy

Cone-Rod Retinal Dystrophy-2

Retinal Cone-Rod Dystrophy 2

Tapetoretinal Degeneration

Cone-Rod Degeneration

Cone Rod Dystrophy

Dystrophy, Cone-Rod

Dystrophy, Cone-Rod, Type 2

Retinitis Pigmentosa

Retinitis Pigmentosa 2

Progressive Cone-Rod Dystrophy
Cystic Fibrosis

Mucoviscidosis

CF

Pseudomonas Aeruginosa, Susceptibility To Chronic Infection By, In Cystic Fibrosis

Pseudomonas Aeruginosa Chronic Infection By, In Cystic Fibrosis

Cystic Fibrosis Lung Disease, Modifier Of

Cystic Fibrosis Of Pancreas

Fibrocystic Disease Of Pancreas

Cf - [Cystic Fibrosis]

Cystic Fibrosis Nos

Fibrocystic Disease

Fibrocystic Disease Of The Pancreas

Mucoviscidosis Of Pancreas

Nonproliferative Fibrocystic Disease

Pancreatic Cystic Fibrosis
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P1698 Reltecimod / Phase 3
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-103023 CLP290 Activator 99.87% 否
HY-110143 CLP257 Activator 99.76% 否
HY-N1388 Tussilagone 99.46% 否
HY-12716A BRL-44408 maleate Antagonist ≥99.0% 否
HY-P1698B Reltecimod TFA 99.78% 否
HY-141487 CLP-3094 Inhibitor ≥95.0% 否
HY-158820 Cosdosiran / 否
HY-158820A Cosdosiran sodium / 否
HY-119102 BPU-11 98.01% 否
HY-149426 SIRT5 inhibitor 7 Inhibitor / 否
HY-163409 CGK012 Inhibitor / 否
HY-E70364 IgdE protease / 否
HY-RS02829 CLP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS02832 CLPS Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta CLPS VGNC VGNC:71264
Mus musculus CLPS MGD MGI:88421
Canis familiaris CLPS VGNC VGNC:54934
Rattus norvegicus CLPS RGD RGD:2363
Bos taurus CLPS VGNC VGNC:53963
Others CLPS NCBI
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