2. Anti-infection Immunology/Inflammation
  3. Bacterial CD28
  4. Reltecimod

Reltecimod (AB-103) 是一种 T 细胞特异性表面糖蛋白 CD28 (TP44) 拮抗剂。Reltecimod对不同的细菌感染、细菌外毒素和内毒素以及电离辐射都有良好的抗性作用。Reltecimod 通过靶向和减弱关键的 CD28/B7-2 共刺激通路来调节炎症反应，而不抑制它。Reltecimod 可用于研究坏死性软组织感染 (NSTIs)。

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Custom Peptide Synthesis

Reltecimod Chemical Structure

Reltecimod Chemical Structure

CAS No. : 1447799-33-8

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Reltecimod 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Reltecimod (AB-103) is a T-cell-specific surface glycoprotein CD28 (TP44) antagonist. Reltecimod has beneficial effects against different bacterial infections, their exotoxins and endotoxins, and ionizing radiation. Reltecimod modulates the inflammatory response by targeting and attenuating the critical CD28/B7-2 co-stimulatory pathway, without inhibiting it. Reltecimod can be used to research necrotizing soft-tissue infections (NSTIs)[1][2].

IC50 & Target

TP44, Bacteria[1][2]
体内研究
(In Vivo)

Reltecimod (1.25-5 mg/kg; i.v.) 可提高感染不同细菌的小鼠的存活率[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Pathogen-free, female BALB/c mice (Acute bacterial peritonitis was induced by i.p. administration with E. coli 018:K1)[2]
Dosage: 1.25 or 5 mg/kg
Administration: i.v.; single dosage; at 4 h post infection
Result: Resulted in 100% survival at single dosage of 5 mg/kg, at day 6.
Resulted in 70% survival at 4 dosage (at 1, 12, 24 and 36 h post infection) of 1.25 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice (NSTI induced by thigh i.m. administration with Streptococcus pyogenes)[2]
Dosage: 2.5 or 5 mg/kg
Administration: i.v.; single dosage; at 1 h, or at 1 h and 12 or 72 h post infection
Result: Resulted in 65% survival at single dosage of 2.5 mg/kg, at day 8.
Resulted in 30% survival at two dosage (1 and 12 h post infection) of 2.5 mg/kg, at day 8.
Resulted in 90% survival at single dosage (1 h post infection) of 5 mg/kg, at day 6.
Animal Model: Pathogen-free, female BALB/c mice [Cecal ligation and puncture (CLP) model][2]
Dosage: 1.25, 2.5, or 5 mg/kg
Administration: i.v.; single dosage
Result: Increased day 7 survival by up to 100%.
Clinical Trial
分子量

1037.19

Formula

C46H72N10O15S
CAS 号
Sequence Shortening

ASPMLVAYDA
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Reltecimod 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Reltecimod1447799-33-8AB-103AB103AB 103BacterialCD28NSTIsTP44T cellE. coliStreptococcus pyogenesCecal ligation and punctureCLPInhibitorinhibitorinhibit

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