Plk3 - polo like kinase 3 Gene

中文名称：马球样激酶 3

种属: Mus musculus

同用名: Cnk; Fnk; PRK; PLK-3

关于 Plk3

功能概要

该基因编码高度保守的丝氨酸/苏氨酸激酶类马球激酶家族的成员。该家族成员的特征在于氨基末端催化结构域和羧基末端二分马球盒结构域，其充当底物结合基序和细胞定位信号。 Polo 样激酶主要与细胞周期调节有关。在小鼠中，据报道这种蛋白质在间期定位于核仁，但在有丝分裂期间检测不到，在前期核仁解离后。蛋白质在胞质分裂之前重新定位到核仁，并且在间期的 G1 期间检测到峰值水平。该基因与进入 S 期的调节有关，RNAi 诱导的耗竭导致无法重新进入细胞周期。缺乏该基因的小鼠在高龄时表现出体重增加和肿瘤发展。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月]

This gene encodes a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal catalytic domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases have primarily been implicated in cell cycle regulation. In mouse, this protein that has been reported to localize to the nucleolus during interphase but is undetectable during Mitosis, following nucleolus dissociation during prophase. The protein relocalizes to the nucleolus just prior to cytokinesis and peak levels are detected during G1 of interphase. This gene has been implicated in regulation of entry into S phase, with RNAi-induced depletion resulting in failure to re-enter the cell cycle. Mice deficient for this gene exhibit increased weight and tumor development at advanced age. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]