1. Cell Cycle/DNA Damage Epigenetics
  2. Polo-like Kinase (PLK) Epigenetic Reader Domain
  3. PLK1-IN-6

PLK1-IN-6 是一种有效和选择性的 PLK1 抑制剂,IC50 值为 0.45 nM。PLK1-IN-6 对癌细胞显示出显着的抗增殖活性。

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PLK1-IN-6 Chemical Structure

PLK1-IN-6 Chemical Structure

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

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Customer Review

查看 Polo-like Kinase (PLK) 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

PLK1-IN-6 is a potent and selective PLK1 inhibitor, with an IC50 of 0.45 nM. PLK1-IN-6 shows significant anti-proliferative activities against cancer cells[1].

IC50 & Target[1]

PLK1

0.45 nM (IC50)

PLK2

5.73 nM (IC50)

PLK3

7.56 nM (IC50)

BRD4

156.3 nM (IC50)

体外研究
(In Vitro)

PLK1-IN-6 (compound 21 g) 对四种肿瘤来源的细胞系显示出显着的抗增殖活性 (MCF-7 IC50=8.64 nM, HCT-116 IC50=26.0 nM, MDA-MB-231 IC50=14.8 nM and MV4-11 IC50=47.4 nM)[1] .
PLK1-IN-6 代谢适中,在人肝微粒体中的半衰期为 25.7 min[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

PLK1-IN-6 (compound 21 g) (1 mg/kg; i.v.) 在 Sprague Dawley 大鼠中表现出良好的半衰期 (10.1 h) 和血浆浓度曲线下面积[1]。< br/> PLK1-IN-6 (10 mg/kg; i.g.) 在 Sprague Dawley 大鼠中表现出低清除率值和高血浆暴露量 (26800 ng•h/mL),具有良好的生物利用度 (11.4%)[1]
PLK1-IN-6 (10 mg/kg; i.g.) 在 Balb/c 小鼠中表现出长半衰期 (2.73 h),高血浆暴露 (11227 ng•h/mL) 和出色的生物利用度 (77.4%)
[ 1]
PLK1-IN-6 (20 mg/kg; i.g.) 对小鼠没有明显的毒性[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

547.65

Formula

C28H37N9O3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Inquiry Information

产品名称:
PLK1-IN-6
目录号:
HY-149100
需求量: