Ctse - cathepsin E Gene

中文名称：组织蛋白酶 E

种属: Mus musculus

同用名: CE; CatE; A430072O03Rik; C920004C08Rik

关于 Ctse

功能概要

该基因编码天冬氨酸蛋白酶和前原蛋白的肽酶 A1 家族的成员，后者经过蛋白水解处理以产生成熟的蛋白质产物。编码的蛋白质可能参与抗原加工和分泌蛋白的成熟。已在神经变性中观察到该基因表达升高。该基因的纯合基因敲除小鼠在肥胖模型中表现出溶酶体贮积症、自噬受损、线粒体异常、皮炎和体重增加减少。 [RefSeq 提供，2015 年 8 月]

This gene encodes a member of the peptidase A1 family of aspartate proteases and preproprotein that is proteolytically processed to generate a mature protein product. The encoded protein may be involved in antigen processing and the maturation of secretory proteins. Elevated expression of this gene has been observed in neurodegeneration. Homozygous knockout mice for this gene exhibit lysosomal storage disorder, impaired Autophagy, mitochondrial abnormalities, dermatitis, and reduced weight gain in an obesity model. [provided by RefSeq, Aug 2015]