Ctsk - cathepsin K Gene

中文名称：组织蛋白酶 K

种属: Mus musculus

同用名: catK; Ms10q; MMS10-Q

关于 Ctsk

功能概要

该基因编码半胱氨酸蛋白酶组织蛋白酶家族的一个成员，该家族在破骨细胞中高度表达，并参与骨骼中胶原蛋白和其他基质蛋白的降解。编码的前原蛋白经过蛋白水解加工以产生成熟的功能性酶。缺乏编码蛋白的小鼠表现出骨密度增加和骨畸形等致密性骨发育不全的表型特征，随着年龄的增长逐渐变得更加明显。 [RefSeq 提供，2016 年 1 月]

This gene encodes a member of the Cathepsin family of cysteine proteases that is highly expressed in osteoclasts and is involved in the degradation of collagen and other matrix proteins in bone. The encoded preproprotein undergoes proteolytic processing to generate a mature, functional Enzyme. Mice lacking the encoded protein exhibit phenotypic features of pycnodysostosis such as increased bone density and bone deformity, which become progressively more pronounced with age. [provided by RefSeq, Jan 2016]