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  3. Dnmt3a - DNA methyltransferase 3A Gene

Dnmt3a - DNA methyltransferase 3A Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: MmuIIIA

基因 ID: 13435 | 基因类型: protein coding

关于 Dnmt3a

功能概要

This is one of two related genes encoding de novo DNA methyltransferases, which are responsible for the establishment of DNA methylation patterns in embryos. Loss of function of this gene causes developmental defects in multiple different organ systems. There is a pseudogene for this gene located on chromosome 3. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Nov 2012]

Dnmt3a 基因产物(3)

mRNA Protein Name
NM_001271753.1 NP_001258682.1 DNA (cytosine-5)-methyltransferase 3A isoform 1
NM_007872.4 NP_031898.1 DNA (cytosine-5)-methyltransferase 3A isoform 1
NM_153743.4 NP_714965.1 DNA (cytosine-5)-methyltransferase 3A isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA (cytosine-5-)-methyltransferase activity IDA
IDA: 通过直接分析推断
9662389 MGI
enables DNA (cytosine-5-)-methyltransferase activity IGI
IGI: 通过遗传相互作用推断
17938196 MGI
enables DNA binding IDA
IDA: 通过直接分析推断
11399089 MGI
enables lncRNA binding IDA
IDA: 通过直接分析推断
25686699 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
11934864 MGI
enables protein-cysteine methyltransferase activity IDA
IDA: 通过直接分析推断
21481189 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA methylation-dependent heterochromatin formation IGI
IGI: 通过遗传相互作用推断
17938196 MGI
involved in autosome genomic imprinting IDA
IDA: 通过直接分析推断
21047779 MGI
acts upstream of or within autosome genomic imprinting IMP
IMP: 通过突变表型推断
11934864 MGI
acts upstream of or within cellular response to amino acid stimulus IDA
IDA: 通过直接分析推断
20548288 MGI
acts upstream of or within cellular response to bisphenol A IDA
IDA: 通过直接分析推断
21980460 MGI
acts upstream of or within epigenetic programming of gene expression IGI
IGI: 通过遗传相互作用推断
10555141 MGI
acts upstream of or within epigenetic programming of gene expression IMP
IMP: 通过突变表型推断
20385583 MGI
acts upstream of or within genomic imprinting IMP
IMP: 通过突变表型推断
15215868 MGI
involved in genomic imprinting IMP
IMP: 通过突变表型推断
15215868 MGI
acts upstream of or within heterochromatin formation IMP
IMP: 通过突变表型推断
22516971 MGI
acts upstream of or within negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: 通过直接分析推断
30834655 MGI
involved in negative regulation of gene expression via chromosomal CpG island methylation IDA
IDA: 通过直接分析推断
21047779 MGI
acts upstream of or within post-embryonic development IDA
IDA: 通过直接分析推断
30834655 MGI
involved in retrotransposon silencing by piRNA-directed DNA methylation IPI
IPI: 通过物理相互作用推断
32674113 MGI
acts upstream of or within spermatogenesis IMP
IMP: 通过突变表型推断
11934864 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in XY body IDA
IDA: 通过直接分析推断
20577743 MGI
located in chromosome, centromeric region IDA
IDA: 通过直接分析推断
15456878 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
15739230 MGI
located in heterochromatin IDA
IDA: 通过直接分析推断
11934864 MGI
located in nucleus IDA
IDA: 通过直接分析推断
14752048 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

DNA (cytosine-5)-methyltransferase 3A

DNA MTase MmuIIIA

DNA methyltransferase MmuIIIA

cysteine methyltransferase DNMT3A

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B2194 γ-Oryzanol Inhibitor 99.66% 否
Pre-clinical Phase
生物活性分子 (12)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-13962 SGI-1027 99.77% 否
HY-151136 DY-46-2 Inhibitor 99.32% 否
HY-144433 DNMT3A-IN-1 Inhibitor 99.94% 否
HY-101925 CM-272 98.70% 否
HY-124131 DS-437 Inhibitor 99.22% 否
HY-111544 EML741 Inhibitor / 否
HY-RS03911 DNMT3A Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-150025 (4aS,8aR)-NPD-001 / 否
HY-172217 DNMT1-IN-5 / 否
HY-176230 DNMT-IN-5 Inhibitor / 否
HY-RS16763 Dnmt3a Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23203 Dnmt3a Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Dnmt3a NCBI NCBI:1788
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