2. Epigenetics
  3. DNA Methyltransferase
  4. DY-46-2

DY-46-2 是一种高效、选择性高的新型非核苷 DNA 甲基转移酶 3A (DNMT3A) 抑制剂，其IC50 值为 1.3 μM。

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DY-46-2 Chemical Structure

DY-46-2 Chemical Structure

CAS No. : 1105110-83-5

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规格 价格 是否有货 数量
10 mM * 1 mL in DMSO ￥4420
In-stock
1 mg ￥2045
In-stock
5 mg ￥4500
In-stock
10 mg ￥7000
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Customer Review

DY-46-2 相关抗体

Top Publications Citing Use of Products

查看 DNA Methyltransferase 亚型特异性产品:

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DNA Methyltransferase DNMT1 DNMT3 MGMT

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

DY-46-2 is a high potency and selectivity novel non-nucleoside DNA methyltransferase 3A (DNMT3A) inhibitor with an IC50 value of 0.39 μM[1].

IC50 & Target

DNMT3A

0.39 μM (IC50)

体外研究
(In Vitro)

DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has an inhibitory activity of DNMT3A with an IC50 value of 0.39 μM, which increases linearly with DNA concentration (IDT-01)[1].
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has inhibitory activity against DNMT1, DNMT3B and G9a with IC50 values of 13.0 μM, 105 μM and ＞500 μM, respectively[1].
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) has cell viability in cancer cells with IC50 values of 0.7 μM, 0.3 μM, 0.7 μM, 0.5 μM, 2.1 μM, 1.7 μM and 91 μM for THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell, respectively[1].
DY-46-2 (0.1-100 μM, 24, 48 and 72 h) markedly inhibits the proliferation of cancer cells and shows low cytotoxicity in peripheral blood mononuclear cells (PBMCs)[1].
DY-46-2 (1 μM, 72 h) obviously decreases DNMT3A protein levels, as well as reactive expression of a silenced TSG (p53) in HCT116 cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

DY-46-2 相关抗体:

Cell Viability Assay[1]

Cell Line: THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell
Concentration: 0.1-100 μM
Incubation Time: 24, 48 and 72 h
Result: Had remarkable inhibitory potency in the dose- and time-dependent manners and no cytotoxicity in non-tumoral PBMCs (IC50 >100 μM).

Cell Proliferation Assay[1]

Cell Line: THP-1, HCT116, U937, K562, A549, DU145 and PBMC cell
Concentration: 0.1-100 μM
Incubation Time: 24, 48 and 72 h
Result: Exhibited high anti-proliferative activity with a micromolar range cytotoxicity in all cancer cells.

Western Blot Analysis[1]

Cell Line: HCT116 cells
Concentration: 1 μM
Incubation Time: 72 h
Result: Decreased DNMT3A and p53 protein levels in the HCT116 cells, apparently sufficient to reactive expression of a silenced TSG (p53).
分子量

446.48

Formula

C19H22N6O5S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 50 mg/mL (111.99 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.2397 mL 11.1987 mL 22.3974 mL
5 mM 0.4479 mL 2.2397 mL 4.4795 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.32%

COA (198 KB) HNMR (146 KB) RP-HPLC (168 KB) LCMS (379 KB)

产品使用指南 (1538 KB)
参考文献

DY-46-2 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2397 mL 11.1987 mL 22.3974 mL 55.9935 mL
5 mM 0.4479 mL 2.2397 mL 4.4795 mL 11.1987 mL
10 mM 0.2240 mL 1.1199 mL 2.2397 mL 5.5994 mL
15 mM 0.1493 mL 0.7466 mL 1.4932 mL 3.7329 mL
20 mM 0.1120 mL 0.5599 mL 1.1199 mL 2.7997 mL
25 mM 0.0896 mL 0.4479 mL 0.8959 mL 2.2397 mL
30 mM 0.0747 mL 0.3733 mL 0.7466 mL 1.8665 mL
40 mM 0.0560 mL 0.2800 mL 0.5599 mL 1.3998 mL
50 mM 0.0448 mL 0.2240 mL 0.4479 mL 1.1199 mL
60 mM 0.0373 mL 0.1866 mL 0.3733 mL 0.9332 mL
80 mM 0.0280 mL 0.1400 mL 0.2800 mL 0.6999 mL
100 mM 0.0224 mL 0.1120 mL 0.2240 mL 0.5599 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

DY-46-21105110-83-5DNA MethyltransferaseDNMTsDNA MTasesDNA methyltransferase 3A (DNMT3A)cancerInhibitorinhibitorinhibit

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产品名称：
DY-46-2
目录号：
HY-151136
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