1. Gene
  2. CYP2A7 - cytochrome P450 family 2 subfamily A member 7 Gene

CYP2A7 - cytochrome P450 family 2 subfamily A member 7 Gene

中文名称:细胞色素 P450 家族 2 亚家族 A 成员 7

种属: Homo sapiens

同用名: CPA7; CPAD; CYP2A; CYPIIA7; P450-IIA4

基因 ID: 1549 | 基因类型: protein coding

关于 CYP2A7

Cytogenetic location: 19q13.2 Genomic coordinates (GRCh38): 19:40,875,439-40,882,231 (from NCBI)

This gene has 5 transcripts (splice variants), 119 orthologues and 15 paralogues. Restricted expression toward liver (RPKM 27.5).

功能概要

该基因编码细胞色素 P450 酶超家族的成员。细胞色素 P450 蛋白是单加氧酶,可催化许多涉及药物代谢和胆固醇、类固醇和其他脂质合成的反应。这种蛋白质定位于内质网;其底物尚未确定。该基因产生两个转录变体,是来自 19q 染色体上 CYP2A、CYP2B 和 CYP2F 亚家族的一大群细胞色素 P450 基因的一部分。[RefSeq 提供,2008 年 7 月]

This gene encodes a member of the Cytochrome P450 superfamily of Enzymes. The Cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of Cholesterol, Steroids and Other lipids. This protein localizes to the endoplasmic reticulum; its substrate has not yet been determined. This gene, which produces two transcript variants, is part of a large cluster of Cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008]

CYP2A7 基因产物(2)

mRNA Protein Name
NM_000764.3 NP_000755.2 cytochrome P450 2A7 isoform 1 precursor
NM_030589.3 NP_085079.2 cytochrome P450 2A7 isoform 2 precursor

CYP2A7 蛋白结构

p450

p450: Cytochrome P450 (34 - 488)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 494 a.a.
蛋白主名 其他名称

cytochrome P450 2A7

cytochrome P450 IIA4

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus CYP2A7 RGD RGD:2465