1. Gene
  2. Htr4 - 5 hydroxytryptamine (serotonin) receptor 4 Gene

Htr4 - 5 hydroxytryptamine (serotonin) receptor 4 Gene

中文名称:5 羟色胺 (血清素) 受体 4

种属: Mus musculus

同用名: 5-HT4; 5HTR4; 5-HT-4; 5-HT

基因 ID: 15562 | 基因类型: protein coding

关于 Htr4

Chromosome 18: 62,457,275-62,629,648 forward strand.GRCm39:CM001011.3

This gene has 4 transcripts (splice variants), 201 orthologues, 32 paralogues and is associated with 11 phenotypes. Biased expression in bladder adult (RPKM 1.5), colon adult (RPKM 1.5) and 6 other tissues.

功能概要

预测该基因编码的蛋白编码的蛋白可启动 G 蛋白偶联血清素受体活性;神经递质受体活性;和血清素结合活性。预计参与G蛋白偶联受体信号通路;化学突触传递;和γ-氨基丁酸信号通路。预测作用于 G 蛋白偶联受体信号通路的上游或内部。预测位于细胞质和细胞膜。预计在树突中活跃。预计是质膜的组成部分。以多种结构表达,包括大脑;胆囊;泌尿生殖系统;直觉;和脊髓。用于研究神经性厌食症。与人类 HTR4(5-羟色胺受体 4)同源。 [由基因组资源联盟提供,2022 年 4 月]

Predicted to enable G protein-coupled serotonin receptor activity; neurotransmitter receptor activity; and serotonin binding activity. Predicted to be involved in G protein-coupled receptor signaling pathway; chemical synaptic transmission; and gamma-aminobutyric acid signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be located in cytoplasm and membrane. Predicted to be active in dendrite. Predicted to be integral component of plasma membrane. Is expressed in several structures, including brain; gallbladder; genitourinary system; gut; and spinal cord. Used to study anorexia nervosa. Orthologous to human HTR4 (5-hydroxytryptamine receptor 4). [provided by Alliance of Genome Resources, Apr 2022]

Htr4 基因产物(10)

mRNA Protein Name
NM_001364959.1 NP_001351888.1 5-hydroxytryptamine receptor 4 isoform 5
NM_001364956.1 NP_001351885.1 5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1 NP_001351886.1 5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1 NP_001351887.1 5-hydroxytryptamine receptor 4 isoform 4
NM_008313.4 NP_032339.2 5-hydroxytryptamine receptor 4 isoform 1
NM_001364956.1 NP_001351885.1 5-hydroxytryptamine receptor 4 isoform 2
NM_001364957.1 NP_001351886.1 5-hydroxytryptamine receptor 4 isoform 3
NM_001364958.1 NP_001351887.1 5-hydroxytryptamine receptor 4 isoform 4
NM_001364959.1 NP_001351888.1 5-hydroxytryptamine receptor 4 isoform 5
NM_008313.4 NP_032339.2 5-hydroxytryptamine receptor 4 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled serotonin receptor activity IDA
IDA: 通过直接分析推断
33299969 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19661922 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
33299969 MGI
involved in maintenance of gastrointestinal epithelium IDA
IDA: 通过直接分析推断
33299969 MGI
involved in mucus secretion IDA
IDA: 通过直接分析推断
33299969 MGI
involved in regulation of postsynapse assembly EXP
EXP: 通过实验结果推断
32060357 MGI
involved in regulation of postsynapse assembly IDA
IDA: 通过直接分析推断
32060357 MGI
involved in regulation of postsynapse assembly IMP
IMP: 通过突变表型推断
32060357 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
32060357 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
29706583 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
32060357 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
33299969 MGI
is active in postsynapse IDA
IDA: 通过直接分析推断
29706583 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Htr4 蛋白结构

7tmA_5-HT4

7tmA_5-HT4: cd15056 (19 - 322)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (20 - 46)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (54 - 80)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (92 - 122)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (135 - 158)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (188 - 217)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (251 - 281)

7tmA_5-HT4

7tmA_5-HT4: cd15056 (290 - 315)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

5-hydroxytryptamine receptor 4

Htr4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Htr4 P97288 SRC Homo sapiens P12931 19661922
种属间
Htr4 P97288 SRC Homo sapiens P12931 19661922
种属间
Htr4 P97288 GRK5 Homo sapiens P34947 19661922
种属间
Htr4 P97288 GRK5 Homo sapiens P34947 19661922
种属间
Htr4 P97288 GRK5 Homo sapiens P34947 19661922
种属间: 跨种属相互作用 种属内: 同种属相互作用

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Htr4 NCBI NCBI:3360