2. Gene
  3. Lrp1 - low density lipoprotein receptor-related protein 1 Gene

Lrp1 - low density lipoprotein receptor-related protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Lrp; A2mr; CD91; b2b1554Clo

基因 ID: 16971 | 基因类型: protein coding

关于 Lrp1

功能概要

Enables calcium ion binding activity; cargo receptor activity; and signaling receptor binding activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway; and positive regulation of transport. Acts upstream of or within several processes, including apoptotic cell clearance; Cholesterol metabolic process; and heart development. Located in external side of plasma membrane. Is integral component of plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and respiratory system. Used to study Alzheimer's disease; cardiomyopathy; congenital diaphragmatic hernia; gastroschisis; and omphalocele. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrp1 基因产物(1)

mRNA Protein Name
NM_008512.2 NP_032538.2 prolow-density lipoprotein receptor-related protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
3266596 MGI
enables cargo receptor activity IMP
IMP: 通过突变表型推断
21289173 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
10772929 MGI
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
31023188 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in amyloid-beta clearance IMP
IMP: 通过突变表型推断
19098903 MGI
involved in amyloid-beta clearance by cellular catabolic process IDA
IDA: 通过直接分析推断
21289173 MGI
involved in amyloid-beta clearance by cellular catabolic process IGI
IGI: 通过遗传相互作用推断
24305823 MGI
involved in amyloid-beta clearance by cellular catabolic process IMP
IMP: 通过突变表型推断
23152628 MGI
involved in amyloid-beta clearance by transcytosis IDA
IDA: 通过直接分析推断
20630619 MGI
involved in aorta morphogenesis IMP
IMP: 通过突变表型推断
19742316 MGI
acts upstream of or within apoptotic cell clearance IMP
IMP: 通过突变表型推断
15647754 MGI
involved in astrocyte activation involved in immune response IGI
IGI: 通过遗传相互作用推断
23152628 MGI
acts upstream of or within cardiac septum development IMP
IMP: 通过突变表型推断
25807483 MGI
involved in cellular response to amyloid-beta IGI
IGI: 通过遗传相互作用推断
23152628 MGI
acts upstream of or within cholesterol metabolic process IMP
IMP: 通过突变表型推断
17920016 MGI
acts upstream of or within coronary vasculature development IMP
IMP: 通过突变表型推断
25807483 MGI
involved in enzyme-linked receptor protein signaling pathway IMP
IMP: 通过突变表型推断
31023188 MGI
involved in lysosomal transport IDA
IDA: 通过直接分析推断
26370502 MGI
involved in negative regulation of SMAD protein signal transduction IMP
IMP: 通过突变表型推断
31023188 MGI
acts upstream of or within negative regulation of Wnt signaling pathway IDA
IDA: 通过直接分析推断
16207730 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
31023188 MGI
involved in negative regulation of platelet-derived growth factor receptor-beta signaling pathway IMP
IMP: 通过突变表型推断
19742316 MGI
involved in negative regulation of smooth muscle cell migration IMP
IMP: 通过突变表型推断
19742316 MGI
involved in negative regulation of transforming growth factor beta receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
31023188 MGI
involved in positive regulation of amyloid-beta clearance IMP
IMP: 通过突变表型推断
26619118 MGI
involved in positive regulation of cholesterol efflux IMP
IMP: 通过突变表型推断
19718435 MGI
involved in positive regulation of lipid transport IMP
IMP: 通过突变表型推断
19718435 MGI
involved in positive regulation of transcytosis IMP
IMP: 通过突变表型推断
26619118 MGI
acts upstream of or within receptor-mediated endocytosis IDA
IDA: 通过直接分析推断
21795536 MGI
involved in receptor-mediated endocytosis IGI
IGI: 通过遗传相互作用推断
21289173 MGI
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
21289173 MGI
involved in regulation of actin cytoskeleton organization IMP
IMP: 通过突变表型推断
19742316 MGI
involved in regulation of cholesterol transport IMP
IMP: 通过突变表型推断
19718435 MGI
involved in regulation of phospholipase A2 activity IMP
IMP: 通过突变表型推断
19718435 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization EXP
EXP: 通过实验结果推断
23760271 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IDA
IDA: 通过直接分析推断
23760271 MGI
involved in regulation of postsynaptic neurotransmitter receptor internalization IMP
IMP: 通过突变表型推断
23760271 MGI
involved in regulation of pulmonary blood vessel remodeling IMP
IMP: 通过突变表型推断
31023188 MGI
involved in transport across blood-brain barrier IMP
IMP: 通过突变表型推断
20630619 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
19299737 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
23760271 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
23760271 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
23760271 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
23760271 MGI
located in membrane IDA
IDA: 通过直接分析推断
15082773 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
3266596 MGI
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
23760271 MGI
is active in postsynaptic density membrane IEP
IEP: 通过表达模式推断
23760271 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

prolow-density lipoprotein receptor-related protein 1

LRP-1

alpha 2-macroglobulin receptor

lipoprotein receptor-related protein

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P4073 ANG1005 98.83% Phase 3
Pre-clinical Phase
生物活性分子 (14)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-172698 DSPE-PEG1000-ANG / 否
HY-172699 DSPE-PEG2000-ANG / 否
HY-172699A DSPE-PEG3400-ANG / 否
HY-172700 DSPE-PEG5000-ANG / 否
HY-P10502 L57 / 否
HY-P10911 IETP2 Ligand / 否
HY-RS01706 C1D Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07792 LRP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07796 LRP1B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-165426 HB-230 / 否
HY-RS16670 Lrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22618 Lrp1b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23105 Lrp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29133 Lrp1b Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lrp1 NCBI NCBI:4035
Canis lupus familiaris Lrp1 NCBI
Rattus norvegicus Lrp1 NCBI NCBI:299858
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