2. Gene
  3. Lrp1 - LDL receptor related protein 1 Gene

Lrp1 - LDL receptor related protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: LRP-1

基因 ID: 299858 | 基因类型: protein coding

关于 Lrp1

功能概要

Enables coreceptor activity and protease binding activity. Involved in several processes, including positive regulation of transport; regulation of cytosolic calcium ion concentration; and regulation of neuron projection development. Located in several cellular components, including axonal growth cone; cytoplasmic vesicle; and neuronal cell body. Used to study diabetes mellitus. Biomarker of Alzheimer's disease; prostate carcinoma in situ; and sciatic neuropathy. Human ortholog(s) of this gene implicated in Alzheimer's disease; keratosis pilaris atrophicans; myocardial infarction; and sciatic neuropathy. Orthologous to human LRP1 (LDL receptor related protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Lrp1 基因产物(1)

mRNA Protein Name
NM_001130490.1 NP_001123962.1 prolow-density lipoprotein receptor-related protein 1 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coreceptor activity IDA
IDA: 通过直接分析推断
18321860 RGD
enables protease binding IPI
IPI: 通过物理相互作用推断
10514495 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
12153398 RGD
enables protein serine/threonine kinase binding IPI
IPI: 通过物理相互作用推断
15272003 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular lipid catabolic process IMP
IMP: 通过突变表型推断
26506094 RGD
involved in cerebral cortex development IEP
IEP: 通过表达模式推断
8930375 RGD
involved in chemoattraction of axon IMP
IMP: 通过突变表型推断
26598525 RGD
involved in negative regulation of apoptotic process IMP
IMP: 通过突变表型推断
17065459 RGD
involved in negative regulation of cell-substrate adhesion IMP
IMP: 通过突变表型推断
20197276 RGD
involved in negative regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
22674573 RGD
involved in negative regulation of focal adhesion assembly IMP
IMP: 通过突变表型推断
20197276 RGD
involved in negative regulation of neuron apoptotic process IDA
IDA: 通过直接分析推断
24086544 RGD
involved in negative regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
17314289 RGD
involved in negative regulation of neuron projection development IMP
IMP: 通过突变表型推断
23132925 RGD
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
24865476 RGD
involved in positive regulation of Schwann cell migration IMP
IMP: 通过突变表型推断
20197276 RGD
involved in positive regulation of axon extension IMP
IMP: 通过突变表型推断
21040802 RGD
involved in positive regulation of axon extension involved in regeneration IDA
IDA: 通过直接分析推断
23867460 RGD
involved in positive regulation of chemokine (C-X-C motif) ligand 2 production IMP
IMP: 通过突变表型推断
21290408 RGD
involved in positive regulation of cholesterol import IMP
IMP: 通过突变表型推断
22454363 RGD
involved in positive regulation of collateral sprouting of injured axon IDA
IDA: 通过直接分析推断
23867460 RGD
involved in positive regulation of cytosolic calcium ion concentration IMP
IMP: 通过突变表型推断
18321860 RGD
involved in positive regulation of insulin secretion involved in cellular response to glucose stimulus IMP
IMP: 通过突变表型推断
24865476 RGD
involved in positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
24086544 RGD
involved in positive regulation of phagocytosis IMP
IMP: 通过突变表型推断
19299462 RGD
involved in positive regulation of protein transport IMP
IMP: 通过突变表型推断
11100124 RGD
involved in positive regulation of vascular associated smooth muscle cell migration IMP
IMP: 通过突变表型推断
20940000 RGD
involved in receptor-mediated endocytosis IMP
IMP: 通过突变表型推断
8626514 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical part of cell IDA
IDA: 通过直接分析推断
20488202 RGD
located in axonal growth cone IDA
IDA: 通过直接分析推断
26598525 RGD
located in clathrin-coated vesicle IDA
IDA: 通过直接分析推断
16190982 RGD
located in dendrite IDA
IDA: 通过直接分析推断
9046007 RGD
located in endosome IDA
IDA: 通过直接分析推断
14701798 RGD
located in insulin-responsive compartment IDA
IDA: 通过直接分析推断
19864425 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
9046007 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

prolow-density lipoprotein receptor-related protein 1

low density lipoprotein receptor-related protein 1

low density lipoprotein-related protein 1 (alpha-2-macroglobulin receptor)

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P4073 ANG1005 98.83% Phase 3
Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-172698 DSPE-PEG1000-ANG / 否
HY-172699 DSPE-PEG2000-ANG / 否
HY-172699A DSPE-PEG3400-ANG / 否
HY-172700 DSPE-PEG5000-ANG / 否
HY-P10502 L57 / 否
HY-P10502A L57 acetate / 否
HY-P10911 IETP2 Ligand / 否
HY-RS01706 C1D Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07792 LRP1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS07796 LRP1B Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-165426 HB-230 / 否
HY-RS16670 Lrp1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS22618 Lrp1b Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23105 Lrp1 Rat Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS29133 Lrp1b Rat Pre-designed siRNA Set A Pre-designed Set / 否
抗体抑制剂 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P990202 Anti-Mouse/Rat/Human LRP1/CD91 Antibody (11H4) Inhibitor ≥95.0% 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lrp1 NCBI NCBI:4035
Canis lupus familiaris Lrp1 NCBI
Mus musculus Lrp1 NCBI NCBI:16971
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