ANG1005  (Synonyms: GRN1005; Paclitaxel trevatide)

ANG1005 (Paclitaxel trevatide) is a brain-penetrating peptide-drug conjugate. ANG1005, a taxane derivative, consists of three paclitaxel (HY-B0015) molecules covalently linked to Angiopep-2, designed to cross the blood-brain and blood-cerebrospinal barriers and to penetrate malignant cells via low density lipoprotein receptor-related protein (LRP1) transport system^[1][2][3].

ANG1005 与游离紫杉醇 (HY-B0015) 相比，显示出显著改善的脑递送和乳腺癌脑转移^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

5109.36

C₂₅₇H₃₀₈N₃₂O₇₉

1075214-55-9

固体

White to off-white

{Paclitaxel-Thr}-Phe-Phe-Tyr-Gly-Gly-Ser-Arg-Gly-{Paclitaxel-Lys}-Arg-Asn-Asn-Phe-{Paclitaxel-Lys}-Thr-Glu-Glu-Tyr

{Paclitaxel-T}FFYGGSRG{Paclitaxel-K}RNNF{Paclitaxel-K}TEEY

Room temperature in continental US; may vary elsewhere.

Sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

• [1]. Thomas FC, et al. Uptake of ANG1005, a novel paclitaxel derivative, through the blood-brain barrier into brain and experimental brain metastases of breast cancer. Pharm Res. 2009 Nov;26(11):2486-94.  [Content Brief]

  [2]. Li F, et al. Targeting metastatic breast cancer with ANG1005, a novel peptide-paclitaxel conjugate that crosses the blood-brain-barrier (BBB). Genes Dis. 2017 Feb 10;4(1):1-3.  [Content Brief]

  [3]. Kumthekar P, et al. ANG1005, a Brain-Penetrating Peptide-Drug Conjugate, Shows Activity in Patients with Breast Cancer with Leptomeningeal Carcinomatosis and Recurrent Brain Metastases. Clin Cancer Res. 2020 Jun 15;26(12):2789-2799.  [Content Brief]