2. Gene
  3. Sp7 - Sp7 transcription factor 7 Gene

Sp7 - Sp7 transcription factor 7 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: C22; Osx; 6430578P22Rik

基因 ID: 170574 | 基因类型: protein coding

关于 Sp7

功能概要

Enables DEAD/H-box RNA helicase binding activity; DNA-binding transcription activator activity, RNA polymerase II-specific; and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within osteoblast differentiation and regulation of transcription by RNA polymerase II. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system; facial prominence mesenchyme; genitourinary system; jaw; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 12. Orthologous to human SP7 (Sp7 transcription factor). [provided by Alliance of Genome Resources, Apr 2022]

Sp7 基因产物(4)

mRNA Protein Name
NM_001348205.1 NP_001335134.1 transcription factor Sp7 isoform 2
NM_130458.4 NP_569725.1 transcription factor Sp7 isoform 1
NM_001348205.1 NP_001335134.1 transcription factor Sp7 isoform 2
NM_130458.4 NP_569725.1 transcription factor Sp7 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DEAD/H-box RNA helicase binding IPI
IPI: 通过物理相互作用推断
17303075 MGI
enables DNA binding IDA
IDA: 通过直接分析推断
11792318 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16041384 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16041384 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19927124 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cementum mineralization IDA
IDA: 通过直接分析推断
31059863 MGI
involved in cementum mineralization IGI
IGI: 通过遗传相互作用推断
31059863 MGI
involved in cementum mineralization IMP
IMP: 通过突变表型推断
31059863 MGI
involved in diphosphate metabolic process IMP
IMP: 通过突变表型推断
31059863 MGI
involved in gene expression IDA
IDA: 通过直接分析推断
31059863 MGI
involved in gene expression IMP
IMP: 通过突变表型推断
31059863 MGI
acts upstream of or within osteoblast differentiation IMP
IMP: 通过突变表型推断
11792318 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16041384 MGI
involved in regulation of hydrolase activity IMP
IMP: 通过突变表型推断
31059863 MGI
acts upstream of or within regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
11792318 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
22886301 MGI
located in nucleus IDA
IDA: 通过直接分析推断
11792318 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transcription factor Sp7

zinc finger protein osterix

Sp7 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Sp7 Q8VI67 RIOX1 Homo sapiens Q9H6W3
Anti Tag CoIP
19927124
种属间
Sp7 Q8VI67 RIOX1 Homo sapiens Q9H6W3
Pull Down
19927124
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15977 (S)-P7C3-OMe / 否
HY-162568 7-tert-Butylfascaplysin / 否
HY-RS13610 SP7 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17939 Sp7 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24410 Sp7 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Sp7 NCBI NCBI:121340
Rattus norvegicus Sp7 NCBI NCBI:300260
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