2. Gene
  3. Kcnk2 - potassium two pore domain channel subfamily K member 2 Gene

Kcnk2 - potassium two pore domain channel subfamily K member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

同用名: Trek-1; rTREK1d

基因 ID: 170899 | 基因类型: protein coding

关于 Kcnk2

功能概要

Enables outward rectifier Potassium Channel activity; Potassium Channel Inhibitor activity; and potassium ion leak channel activity. Involved in several processes, including cochlea development; negative regulation of cardiac muscle cell proliferation; and positive regulation of cellular response to hypoxia. Located in several cellular components, including apical plasma membrane; astrocyte projection; and calyx of Held. Is integral component of plasma membrane. Used to study transient cerebral ischemia. Biomarker of brain ischemia; congestive heart failure; myocardial infarction; and transient cerebral ischemia. Orthologous to human KCNK2 (potassium two pore domain channel subfamily K member 2). [provided by Alliance of Genome Resources, Apr 2022]

Kcnk2 基因产物(2)

mRNA Protein Name
NM_172041.2 NP_742038.2 potassium channel subfamily K member 2 isoform 1
NM_172042.2 NP_742039.1 potassium channel subfamily K member 2 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ligand-gated channel activity IDA
IDA: 通过直接分析推断
23021213 RGD
enables outward rectifier potassium channel activity IDA
IDA: 通过直接分析推断
11319556 RGD
enables potassium channel inhibitor activity IDA
IDA: 通过直接分析推断
24196565 RGD
enables potassium ion leak channel activity IDA
IDA: 通过直接分析推断
11319556 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16750514 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cardiac ventricle development IEP
IEP: 通过表达模式推断
24705172 RGD
involved in cellular response to arachidonate IDA
IDA: 通过直接分析推断
26919430 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
24705172 RGD
involved in cochlea development IEP
IEP: 通过表达模式推断
15094499 RGD
involved in detection of mechanical stimulus involved in sensory perception of touch IMP
IMP: 通过突变表型推断
31630908 RGD
involved in glutamate secretion IDA
IDA: 通过直接分析推断
23021213 RGD
involved in memory IEP
IEP: 通过表达模式推断
14730890 RGD
involved in negative regulation of DNA biosynthetic process IMP
IMP: 通过突变表型推断
23271285 RGD
involved in negative regulation of cardiac muscle cell proliferation IMP
IMP: 通过突变表型推断
24705172 RGD
involved in neuronal action potential IMP
IMP: 通过突变表型推断
31630908 RGD
involved in positive regulation of cellular response to hypoxia IMP
IMP: 通过突变表型推断
24705172 RGD
involved in potassium ion transmembrane transport IDA
IDA: 通过直接分析推断
11319556 RGD
involved in response to axon injury IEP
IEP: 通过表达模式推断
10790857 RGD
involved in response to mechanical stimulus IEP
IEP: 通过表达模式推断
17828492 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
15261098 RGD
located in astrocyte projection IDA
IDA: 通过直接分析推断
25062759 RGD
located in axon IDA
IDA: 通过直接分析推断
10790857 RGD
located in axon terminus IDA
IDA: 通过直接分析推断
18838117 RGD
located in calyx of Held IDA
IDA: 通过直接分析推断
15261098 RGD
located in cell surface IDA
IDA: 通过直接分析推断
22910181 RGD
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
24196565 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
19571146 RGD
located in node of Ranvier IDA
IDA: 通过直接分析推断
31630908 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
24196565 RGD
located in plasma membrane IMP
IMP: 通过突变表型推断
19571146 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

potassium channel subfamily K member 2

TREK-1 K(+) channel subunit

arachidonic acid sensitive tandem pore domain potassium channel

ion transport membrane protein

outward rectifying potassium channel protein TREK-1

potassium channel, two pore domain subfamily K, member 2

stretch-activated

Kcnk2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
Kcnk2 Q920B6 GNG4 Homo sapiens P50150
Anti Tag CoIP
23021213
种属间
Kcnk2 Q920B6 GNG4 Homo sapiens P50150
Y2H
23021213
种属间
Kcnk2 Q920B6 GNG4 Homo sapiens P50150
Pull Down
23021213
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-B1500 2,2,2-Trichloroethanol Agonist 99.53% 否
HY-RS07158 KCNK2 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18069 Kcnk2 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS24544 Kcnk2 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Kcnk2 NCBI NCBI:3776
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