2. Gene
  3. Lyn - LYN proto-oncogene, Src family tyrosine kinase Gene

Lyn - LYN proto-oncogene, Src family tyrosine kinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Hck-2; p53Lyn; p56Lyn

基因 ID: 17096 | 基因类型: protein coding

关于 Lyn

功能概要

Enables SH3 domain binding activity and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including immune response-regulating signaling pathway; immune system development; and regulation of signal transduction. Acts upstream of or within several processes, including B cell receptor signaling pathway; peptidyl-tyrosine phosphorylation; and regulation of release of sequestered calcium ion into cytosol. Located in several cellular components, including membrane raft; nucleus; and plasma membrane. Part of protein-containing complex. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system gland; liver and biliary system; and nervous system. Used to study systemic lupus erythematosus. Orthologous to human Lyn (Lyn proto-oncogene, Src family tyrosine kinase). [provided by Alliance of Genome Resources, Apr 2022]

Lyn 基因产物(2)

mRNA Protein Name
NM_001111096.1 NP_001104566.1 tyrosine-protein kinase Lyn isoform A
NM_010747.2 NP_034877.2 tyrosine-protein kinase Lyn isoform B
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
19064729 MGI
enables non-membrane spanning protein tyrosine kinase activity IMP
IMP: 通过突变表型推断
28098138 MGI
enables phosphatidylinositol 3-kinase activator activity IMP
IMP: 通过突变表型推断
8128248 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
8395016 MGI
enables protein kinase activity IDA
IDA: 通过直接分析推断
9000133 MGI
enables protein tyrosine kinase activity EXP
EXP: 通过实验结果推断
8629002 MGI
enables protein tyrosine kinase activity IDA
IDA: 通过直接分析推断
7499277 MGI
enables protein-containing complex binding IPI
IPI: 通过物理相互作用推断
19064729 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in B cell homeostasis IMP
IMP: 通过突变表型推断
9252121 MGI
acts upstream of or within B cell receptor signaling pathway IDA
IDA: 通过直接分析推断
7499277 MGI
acts upstream of or within B cell receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
23509253 MGI
involved in Fc receptor mediated inhibitory signaling pathway IMP
IMP: 通过突变表型推断
16272347 MGI
involved in Fc receptor mediated stimulatory signaling pathway IMP
IMP: 通过突变表型推断
16272347 MGI
acts upstream of or within autophagy IGI
IGI: 通过遗传相互作用推断
33941276 MGI
acts upstream of or within autophagy IMP
IMP: 通过突变表型推断
33941276 MGI
acts upstream of or within cell morphogenesis IGI
IGI: 通过遗传相互作用推断
33941276 MGI
involved in dendritic cell differentiation IMP
IMP: 通过突变表型推断
16034130 MGI
involved in erythrocyte differentiation IMP
IMP: 通过突变表型推断
10713104 MGI
involved in hemopoiesis IMP
IMP: 通过突变表型推断
11672542 MGI
involved in immune response-regulating cell surface receptor signaling pathway IMP
IMP: 通过突变表型推断
9252121 MGI
acts upstream of or within intracellular signal transduction IDA
IDA: 通过直接分析推断
9000133 MGI
involved in lipopolysaccharide-mediated signaling pathway IMP
IMP: 通过突变表型推断
20385881 MGI
involved in negative regulation of B cell proliferation IMP
IMP: 通过突变表型推断
9252121 MGI
involved in negative regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
14525964 MGI
involved in negative regulation of MAP kinase activity IMP
IMP: 通过突变表型推断
9252121 MGI
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
14726379 MGI
involved in negative regulation of intracellular signal transduction IMP
IMP: 通过突变表型推断
14525964 MGI
involved in negative regulation of mast cell proliferation IMP
IMP: 通过突变表型推断
14525964 MGI
involved in negative regulation of myeloid leukocyte differentiation IMP
IMP: 通过突变表型推断
11672542 MGI
involved in negative regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
14525964 MGI
involved in negative regulation of toll-like receptor 2 signaling pathway IMP
IMP: 通过突变表型推断
20385881 MGI
involved in negative regulation of toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
20385881 MGI
acts upstream of or within neuroinflammatory response IGI
IGI: 通过遗传相互作用推断
33941276 MGI
acts upstream of or within neuron projection development IMP
IMP: 通过突变表型推断
19118221 MGI
acts upstream of or within peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
7499277 MGI
involved in peptidyl-tyrosine phosphorylation IDA
IDA: 通过直接分析推断
11672542 MGI
involved in peptidyl-tyrosine phosphorylation IMP
IMP: 通过突变表型推断
28098138 MGI
involved in platelet degranulation IMP
IMP: 通过突变表型推断
20189992 MGI
involved in positive regulation of cell migration IMP
IMP: 通过突变表型推断
11435302 MGI
involved in positive regulation of cell population proliferation IMP
IMP: 通过突变表型推断
10713104 MGI
involved in positive regulation of dendritic cell apoptotic process IMP
IMP: 通过突变表型推断
16116174 MGI
acts upstream of or within protein autophosphorylation IDA
IDA: 通过直接分析推断
7499277 MGI
involved in protein autophosphorylation IDA
IDA: 通过直接分析推断
11672542 MGI
involved in regulation of B cell apoptotic process IMP
IMP: 通过突变表型推断
9064343 MGI
involved in regulation of B cell receptor signaling pathway IMP
IMP: 通过突变表型推断
11672542 MGI
involved in regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
9252121 MGI
involved in regulation of cytokine production IMP
IMP: 通过突变表型推断
16272347 MGI
involved in regulation of erythrocyte differentiation IMP
IMP: 通过突变表型推断
10594694 MGI
involved in regulation of inflammatory response IMP
IMP: 通过突变表型推断
16034130 MGI
involved in regulation of mast cell activation IMP
IMP: 通过突变表型推断
16272347 MGI
involved in regulation of mast cell degranulation IMP
IMP: 通过突变表型推断
16272347 MGI
involved in regulation of platelet aggregation IMP
IMP: 通过突变表型推断
20189992 MGI
acts upstream of or within regulation of release of sequestered calcium ion into cytosol IGI
IGI: 通过遗传相互作用推断
23509253 MGI
involved in response to hormone IDA
IDA: 通过直接分析推断
10713104 MGI
involved in tolerance induction to self antigen IMP
IMP: 通过突变表型推断
9252121 MGI
involved in toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
28098138 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
10713104 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
11826099 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10713104 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
19064729 MGI
part of protein-containing complex IDA
IDA: 通过直接分析推断
12681493 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein kinase Lyn

V-yes-1 Yamaguchi sarcoma viral related oncogene homolog

Yamaguchi sarcoma viral (v-yes-1) oncogene homolog

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-157442 GLPG3312 Inhibitor 98.57% Phase 1
Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-176194 Antifibrotic agent 1 Inhibitor / 否
HY-175437 MRT-7612 Degrader / 否
HY-178014 SIK1-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Lyn NCBI NCBI:4067
Macaca fascicularis Lyn NCBI NCBI:102118154
Rattus norvegicus Lyn NCBI NCBI:81515
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