2. Immunology/Inflammation Protein Tyrosine Kinase/RTK
  3. Salt-inducible Kinase (SIK) Src
  4. SIK1-IN-1

SIK1-IN-1 (Compound 27) 是一种选择性盐诱导激酶 1 (SIK1) 抑制剂，其对 SIK1 的 IC50 为 0.7 nM，优于对 SIK2 和 SIK3 的抑制效力。SIK1-IN-1 对 HEK293 细胞和 PBMC 无细胞毒性 (最高浓度为 30 μM)。SIK1-IN-1 还对 392 种激酶，尤其是酪氨酸激酶 (如 FGR、HCK 和 LYN) 具有强效抑制活性。

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SIK1-IN-1

SIK1-IN-1 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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SIK1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Salt-inducible Kinase (SIK) 亚型特异性产品:

查看所有亚型
SIK1 SIK2 SIK3

查看 Src 亚型特异性产品:

查看所有亚型
Lck Fyn Blk Fgr Hck Lyn Yes SRC-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SIK1-IN-1 (Compound 27) is a selective Salt-inducible kinase 1 (SIK1) inhibitor with an IC50 of 0.7  nM for SIK1 over SIK2 and SIK3. SIK1-IN-1 has no cytotoxicity against HEK293 cells and PBMCs (maximum concentration of 30 μM). SIK1-IN-1 also has potent inhibitory activities for 392 kinases, in particular tyrosine kinases, such as FGR, HCK and LYN)[1].

IC50 & Target[1]

SIK1

0.7 nM (IC50)

SIK2

75.3 nM (IC50)

SIK3

240 nM (IC50)

Lyn

<1.5 nM (IC50)

Hck

<3 nM (IC50)

Fgr

<3 nM (IC50)

Yes

<3 nM (IC50)

Lck

3.7 nM (IC50)

分子量

409.87

Formula

C21H20ClN5O2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SIK1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SIK1-IN-1Salt-inducible Kinase (SIK)SrcSalt-inducible kinase 1SIK1Tyrosine kinasesHEK293 cellsPBMCsInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-178014
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