2. Gene
  3. Opa1 - OPA1, mitochondrial dynamin like GTPase Gene

Opa1 - OPA1, mitochondrial dynamin like GTPase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Rattus norvegicus

基因 ID: 171116 | 基因类型: protein coding

关于 Opa1

功能概要

Enables kinase binding activity. Involved in several processes, including mitochondrion organization; positive regulation of cellular component organization; and sensory organ development. Located in cytosol. Is extrinsic component of mitochondrial inner membrane. Colocalizes with mitochondrion. Used to study transient cerebral ischemia. Biomarker of several diseases, including artery disease (multiple); chronic kidney disease; fatty liver disease; ocular hypertension; and rhinitis. Human ortholog(s) of this gene implicated in Behr syndrome; dominant optic atrophy plus syndrome; mitochondrial DNA depletion syndrome 14; optic atrophy; and optic atrophy 1. Orthologous to human OPA1 (OPA1 mitochondrial Dynamin like GTPase). [provided by Alliance of Genome Resources, Apr 2022]

Opa1 基因产物(2)

mRNA Protein Name
NM_133585.3 NP_598269.3 dynamin-like 120 kDa protein, mitochondrial precursor
NM_133585.3 NP_598269.3 dynamin-like 120 kDa protein, mitochondrial precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables kinase binding IPI
IPI: 通过物理相互作用推断
23150663 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
20678484 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in calcium import into the mitochondrion IMP
IMP: 通过突变表型推断
24085037 RGD
involved in cellular response to L-glutamate IEP
IEP: 通过表达模式推断
28761318 RGD
involved in cellular response to glucose stimulus IEP
IEP: 通过表达模式推断
27684054 RGD
involved in cellular response to hypoxia IEP
IEP: 通过表达模式推断
27833818 RGD
involved in cochlea development IEP
IEP: 通过表达模式推断
17828551 RGD
involved in intracellular distribution of mitochondria IMP
IMP: 通过突变表型推断
19605646 RGD
involved in mitochondrion organization IDA
IDA: 通过直接分析推断
16778770 RGD
involved in mitochondrion organization IMP
IMP: 通过突变表型推断
19605646 RGD
involved in positive regulation of cellular response to insulin stimulus IMP
IMP: 通过突变表型推断
24085037 RGD
involved in positive regulation of dendrite development IMP
IMP: 通过突变表型推断
23543485 RGD
involved in positive regulation of dendritic spine morphogenesis IMP
IMP: 通过突变表型推断
19605646 RGD
involved in positive regulation of insulin receptor signaling pathway IMP
IMP: 通过突变表型推断
24085037 RGD
involved in positive regulation of mitochondrial fusion IMP
IMP: 通过突变表型推断
22442078 RGD
involved in positive regulation of neuron maturation IMP
IMP: 通过突变表型推断
23543485 RGD
involved in response to curcumin IEP
IEP: 通过表达模式推断
27801955 RGD
involved in response to electrical stimulus IEP
IEP: 通过表达模式推断
26513006 RGD
involved in response to muscle activity IEP
IEP: 通过表达模式推断
28536949 RGD
involved in response to nutrient levels IEP
IEP: 通过表达模式推断
25336449 RGD
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
15505078 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in mitochondrial inner membrane IDA
IDA: 通过直接分析推断
16778770 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

dynamin-like 120 kDa protein, mitochondrial

RN protein

mitochondrial OPA1

optic atrophy 1 (autosomal dominant)

optic atrophy 1 homolog

optic atrophy 1-like protein

optic atrophy protein 1 homolog

相关产品

Pre-clinical Phase
生物活性分子 (11)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-126124 AP39 96.35% 否
HY-116364B AZT triphosphate tetraammonium 99.25% 否
HY-158162 SIRT3 activator 1 Activator 98.14% 否
HY-RS08281 MED12 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-116364 AZT triphosphate / 否
HY-116364A AZT triphosphate TEA / 否
HY-RS09789 OPA1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS16968 Opa1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-131037 MB-0223 Inhibitor / 否
HY-RS18290 Med12 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23411 Opa1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Opa1 NCBI NCBI:4976
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