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  3. AZT triphosphate

AZT triphosphate  (Synonyms: 3'-Azido-3'-deoxythymidine-5'-triphosphate)

目录号: HY-116364
产品使用指南

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) 是一种 Zidovudine (AZT) 的活性三磷酸酯代谢产物。AZT triphosphate 具有抗逆转录病毒的活性,并抑制 HIV 复制。AZT triphosphate 还可抑制 HBVDNA 聚合酶。AZT triphosphate 可激活线粒体介导的凋亡 (apoptosis) 途径。

该游离形式化合物不稳定,推荐具有相同生物学活性的稳定盐形式 AZT triphosphate tetraammonium

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AZT triphosphate Chemical Structure

AZT triphosphate Chemical Structure

CAS No. : 92586-35-1

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AZT triphosphate 的其他形式现货产品:

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  • 生物活性

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生物活性

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate also inhibits the DNA polymerase of HBV. AZT triphosphate activates the mitochondria-mediated apoptosis pathway[1][2][3].

体外研究
(In Vitro)

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) accumulation disrupts the mitochondrial tubular network in H9c2 cells through Treatment with 100 µM Zidovudine (AZT) for 48h. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

507.18

Formula

C10H16N5O13P3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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AZT triphosphate
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