1. Anti-infection
    Cell Cycle/DNA Damage
    Immunology/Inflammation
    NF-κB
    Metabolic Enzyme/Protease
    Apoptosis
  2. HIV
    DNA/RNA Synthesis
    HBV
    Reactive Oxygen Species
    Apoptosis
  3. AZT triphosphate TEA

AZT triphosphate TEA (Synonyms: 3'-Azido-3'-deoxythymidine-5'-triphosphate TEA)

目录号: HY-116364A
产品使用指南

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) 是一种 Zidovudine (AZT) 的活性三磷酸酯代谢产物。AZT triphosphate TFA 具有抗逆转录病毒的活性,并抑制 HIV 复制。AZT triphosphate TFA 还可抑制 HBVDNA 聚合酶。AZT triphosphate TFA 可激活线粒体介导的凋亡 (apoptosis) 途径。

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AZT triphosphate TEA Chemical Structure

AZT triphosphate TEA Chemical Structure

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Description

AZT triphosphate TFA (3'-Azido-3'-deoxythymidine-5'-triphosphate TFA) is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TFA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TFA also inhibits the DNA polymerase of HBV. AZT triphosphate TFA activates the mitochondria-mediated apoptosis pathway[1][2][3].

IC50 & Target

HIV[2]
HBV[3]
DNA polymerase[3]
Reactive oxygen species (ROS)[1]

In Vitro

Treatment with 100 µM Zidovudine (AZT) for 48h disrupts the mitochondrial tubular network via accumulation of AZT triphosphate (AZT-TP) in H9c2 cells. AZT triphosphate accumulation causes downregulation of Opa1 and upregulation of Drp1. AZT triphosphate causes mitochondrial dysfunction, increases the production of cytotoxic reactive oxygen species (ROS), and impairs the balance of the mitochondrial quality control system in H9c2 cell model established from rat embryonic myoblasts[1].

Formula

C₁₀H₁₆N₅O₁₃P₃.xC₆H₁₅N

SMILES

O=C(NC(C(C)=C1)=O)N1[C@H](O2)C[C@H](N=[N+]=[N-])[C@H]2COP(O)(OP(OP(O)(O)=O)(O)=O)=O.CCN(CC)CC.[x]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

AZT triphosphate3'-Azido-3'-deoxythymidine-5'-triphosphateHIVDNA/RNA SynthesisHBVReactive Oxygen SpeciesApoptosisHuman immunodeficiency virusHepatitis B virusZidovudinetriphosphatemetaboliteROSmitochondrialcardiomyopathyOpa1Drp1cytotoxicityantiretroviralInhibitorinhibitorinhibit

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产品名称:
AZT triphosphate TEA
目录号:
HY-116364A
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