1. Anti-infection Cell Cycle/DNA Damage Immunology/Inflammation NF-κB Metabolic Enzyme/Protease Apoptosis
  2. HIV DNA/RNA Synthesis HBV Reactive Oxygen Species Apoptosis
  3. AZT triphosphate TEA

AZT triphosphate TEA  (Synonyms: 3'-Azido-3'-deoxythymidine-5'-triphosphate TEA)

目录号: HY-116364A
产品使用指南

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA 是一种 Zidovudine (AZT) 的活性三磷酸酯代谢产物。AZT triphosphate TEA 具有抗逆转录病毒的活性,并抑制 HIV 复制。AZT triphosphate TEA 还可抑制 HBVDNA 聚合酶。AZT triphosphate TEA 可激活线粒体介导的凋亡 (apoptosis) 途径。

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AZT triphosphate TEA Chemical Structure

AZT triphosphate TEA Chemical Structure

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  • 生物活性

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生物活性

AZT triphosphate (3'-Azido-3'-deoxythymidine-5'-triphosphate) TEA is a active triphosphate metabolite of Zidovudine (AZT). AZT triphosphate TEA exhibits antiretroviral activity and inhibits replication of HIV. AZT triphosphate TEA also inhibits the DNA polymerase of HBV. AZT triphosphate TEA activates the mitochondria-mediated apoptosis pathway[1][2][3].

体外研究
(In Vitro)

AZT triphosphate TEA (3'-Azido-3'-deoxythymidine-5'-triphosphate) 积累破坏 H9c2 细胞中的线粒体管状网络,通过 100 μM 齐多夫定 (AZT) 处理 48 小时。AZT triphosphate TEA TEA 积累导致 Opa1 的下调和 Drp1 的上调。AZT triphosphate TEA TEA 引起线粒体功能障碍,增加细胞毒性活性氧 (ROS) 的产生,并损害大鼠胚胎成肌细胞 H9c2 细胞模型中线粒体质量控制系统的平衡[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

608.37

Formula

C16H31N6O13P3

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
AZT triphosphate TEA
目录号:
HY-116364A
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