2. Gene
  3. Trpm8 - transient receptor potential cation channel, subfamily M, member 8 Gene

Trpm8 - transient receptor potential cation channel, subfamily M, member 8 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CMR1; TRPP8; LTRPC6; Trp-p8; LTrpC-6

基因 ID: 171382 | 基因类型: protein coding

关于 Trpm8

功能概要

Enables Calcium Channel activity and identical protein binding activity. Involved in positive regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including cellular calcium ion homeostasis; response to cold; and thermoception. Located in external side of plasma membrane. Is expressed in dorsal root ganglion; inferior vagus ganglion; and vagus ganglion. Orthologous to human TRPM8 (transient receptor potential cation channel subfamily M member 8). [provided by Alliance of Genome Resources, Apr 2022]

Trpm8 基因产物(1)

mRNA Protein Name
NM_134252.5 NP_599013.1 transient receptor potential cation channel subfamily M member 8
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium channel activity IDA
IDA: 通过直接分析推断
11893340 MGI
enables calcium channel activity IMP
IMP: 通过突变表型推断
17538622 MGI
enables identical protein binding IPI
IPI: 通过物理相互作用推断
17015441 MGI
enables monoatomic ion channel activity IDA
IDA: 通过直接分析推断
11893340 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
18455988 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within calcium ion transport IDA
IDA: 通过直接分析推断
17015441 MGI
acts upstream of or within intracellular calcium ion homeostasis IDA
IDA: 通过直接分析推断
11893340 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
22241835 MGI
acts upstream of or within response to cold IDA
IDA: 通过直接分析推断
12654248 MGI
acts upstream of or within response to cold IMP
IMP: 通过突变表型推断
17481391 MGI
acts upstream of or within response to temperature stimulus IDA
IDA: 通过直接分析推断
11893340 MGI
acts upstream of or within thermoception IDA
IDA: 通过直接分析推断
12654248 MGI
acts upstream of or within thermoception IMP
IMP: 通过突变表型推断
17481391 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
17015441 MGI
located in membrane IDA
IDA: 通过直接分析推断
11893340 MGI
located in membrane raft IDA
IDA: 通过直接分析推断
19176480 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

transient receptor potential cation channel subfamily M member 8

TRP ion channel TRPM8

long transient receptor potential channel 6

transient receptor potential p8

相关产品

Approval
生物活性分子 (4)
目录号 产品名 作用方式
纯度 是否罕见病
HY-75161 (-)-Menthol Activator 99.79% 否
HY-B0985 Phenazopyridine hydrochloride Antagonist 99.84% 否
HY-B1173 (+)-Camphor Inhibitor ≥98.0% 否
HY-B0985A Phenazopyridine Antagonist 99.93% 否
Clinical Phase
生物活性分子 (6)
目录号 产品名 作用方式
纯度 Phase
HY-108449 Acoltremon Agonist 99.13% Phase 3
HY-109087 Elismetrep Antagonist 99.42% Phase 2
HY-112703 AMG 333 Antagonist 99.82% Phase 1
HY-16162A D-3263 hydrochloride Agonist 98.03% Phase 1
HY-115506 PF-05105679 Antagonist 99.84% Phase 1
HY-16162 D-3263 Agonist / Phase 1
Pre-clinical Phase
生物活性分子 (32)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-11062 Icilin Agonist 99.26% 否
HY-100345 AMTB hydrochloride Inhibitor 99.18% 否
HY-101507 Zerencotrep Inhibitor 99.47% 否
HY-19960 BCTC 99.66% 否
HY-18662 RQ-00203078 Antagonist 99.84% 否
HY-N8264 Moringin Agonist 99.95% 否
HY-112430 TRPM8 antagonist 2 Antagonist 98.01% 否
HY-19976 RN-1747 Agonist 99.27% 否
HY-144372 TRPV1 antagonist 3 Antagonist 98.97% 否
HY-110181 M8-B Antagonist 99.89% 否
HY-104059 AMG2850 Antagonist 99.89% 否
HY-145124 TRPM8 antagonist 3 Antagonist 99.51% 否
HY-110199 TC-I 2014 Antagonist ≥99.0% 否
HY-N7117 1,4-Cineole Activator ≥95.0% 否
HY-W014394 Vanillyl butyl ether Agonist 99.67% 否
HY-160900 RN-1665 Antagonist 99.93% 否
HY-126593 Cryosim-3 99.90% 否
HY-130074 FEMA 4809 Agonist 99.25% 否
HY-W014325 TRPM8 agonist WS-3 Agonist 99.35% 否
HY-108461 TRPM8-IN-1 Inhibitor / 否
HY-N7536 Voacangine 98.78% 否
HY-104061 AMG8788 Antagonist / 否
HY-104062 AMG9678 Antagonist / 否
HY-15056 AMG 9090 Agonist / 否
HY-174825 TRPM8 antagonist 4 / 否
HY-174846 TRPM8 antagonist 4 prodrug / 否
HY-RS15118 TRPM8 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-W711474 (-)-Menthol-d4 / 否
HY-N1369S1 Menthol-d2 Modulator / 否
HY-N9484S Menthofuran-13C2 / 否
HY-RS16771 Trpm8 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23211 Trpm8 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Trpm8 NCBI NCBI:79054
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