2. Membrane Transporter/Ion Channel Neuronal Signaling Others
  3. Calcium Channel Isotope-Labeled Compounds
  4. Menthol-d2

Menthol-d2 是氘代标记的 Menthol (HY-N1369)。Menthol 是一种止痛剂和 TRPM8 调节剂。TRPM8 是冷温度传感离子通道，Menthol 可调节 TRPM8发挥镇痛和抗刺激机制。Menthol 通过抑制神经元细胞膜的 Ca++ 电流，而刺激冷感受器、产生凉的感觉。

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Menthol-d<sub>2</sub> Chemical Structure

Menthol-d2 Chemical Structure

CAS No. : 1335435-38-5

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规格 是否有货
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Other Forms of Menthol-d2:

Menthol-d2 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Menthol-d2 is deuterated labeled Menthol (HY-N1369). Menthol is an analgesic and TRPM8 modulator. TRPM8 is a cold temperature sensing ion channel, and Menthol can regulate TRPM8 to exert analgesic and anti-irritation mechanisms. Menthol stimulates cold receptors and produces a cooling sensation by inhibiting Ca++ currents in neuronal cell membranes[1][2][3].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被纳入药物分子中，主要作为药物开发过程中定量的示踪剂。氘化引起了人们的关注，因为它可能影响药物的药代动力学和代谢谱[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Menthol-d2 相关抗体:
体内研究
(In Vivo)

Menthol (10-200 μg/mL; po; 单剂量) 可以减少小鼠口服尼古丁 (200 μg/mL) 的厌恶作用，并且在较高浓度下，Menthol 本身会产生刺激物[3]。
Menthol 还通过 TRPM8 可以强烈抑制呼吸道刺激反应，并且会增加血液中的可替宁。Menthol 作为卷烟添加剂，可能会促进吸烟和尼古丁成瘾[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

158.28

Formula

C10H18D2O
CAS 号
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Menthol-d2 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Menthol-d21335435-38-5Calcium ChannelIsotope-Labeled CompoundsCa2+ channelsCa channelsbiochemical assayreagentInhibitorinhibitorinhibit

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