Mdm2 - transformed mouse 3T3 cell double minute 2 Gene

中文名称：转化小鼠3 T3 细胞双分2

种属: Mus musculus

同用名: Mdm-2; 1700007J15Rik

关于 Mdm2

功能概要

该基因编码的蛋白可启动 p53 结合活性和泛素蛋白连接酶活性。参与细胞凋亡过程和肌肉细胞分化的正调节。作用于多个过程的上游或内部，包括血管重塑；循环系统发育；并穿越有丝分裂细胞周期的起始控制点。位于细胞质和核仁中。以多种结构表达，包括消化系统；胚胎外胚层；泌尿生殖系统；呼吸系统;和感觉器官。该基因的人类直系同源物与慢性粒细胞白血病有关；内分泌腺癌（多发）；胶质母细胞瘤;鱼鳞病;和肉瘤。与人类 MDM2 同源（MDM2 原癌基因）。 [由基因组资源联盟提供，2022 年 4 月]

Enables p53 binding activity and ubiquitin protein Ligase activity. Involved in apoptotic process and positive regulation of muscle cell differentiation. Acts upstream of or within several processes, including blood vessel remodeling; circulatory system development; and traversing start control point of mitotic cell cycle. Located in cytoplasm and nucleolus. Is expressed in several structures, including alimentary system; embryo ectoderm; genitourinary system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in chronic myeloid leukemia; endocrine gland Cancer (multiple); glioblastoma; ichthyosis; and sarcoma. Orthologous to human MDM2 (MDM2 proto-oncogene). [provided by Alliance of Genome Resources, Apr 2022]