2. Gene
  3. Nck1 - non-catalytic region of tyrosine kinase adaptor protein 1 Gene

Nck1 - non-catalytic region of tyrosine kinase adaptor protein 1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: Nck; Nck-1; 6330586M15Rik; D230010O13Rik

基因 ID: 17973 | 基因类型: protein coding

关于 Nck1

功能概要

Enables Ephrin Receptor binding activity; eukaryotic initiation factor eIF2 binding activity; and protein domain specific binding activity. Involved in regulation of cellular macromolecule biosynthetic process and regulation of response to endoplasmic reticulum stress. Acts upstream of or within several processes, including Ephrin Receptor signaling pathway; plasma membrane bounded cell projection assembly; and positive regulation of cellular component organization. Located in cell-cell junction and vesicle membrane. Is expressed in several structures, including extraembryonic component; hemolymphoid system gland; male reproductive gland or organ; nervous system; and somite. Orthologous to human NCK1 (NCK adaptor protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Nck1 基因产物(2)

mRNA Protein Name
NM_001324530.1 NP_001311459.1 cytoplasmic protein NCK1 isoform 2
NM_010878.3 NP_035008.2 cytoplasmic protein NCK1 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ephrin receptor binding IPI
IPI: 通过物理相互作用推断
19505147 MGI
enables eukaryotic initiation factor eIF2 binding IPI
IPI: 通过物理相互作用推断
11959995 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14580336 MGI
enables protein domain specific binding IPI
IPI: 通过物理相互作用推断
8438166 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within actin filament organization IMP
IMP: 通过突变表型推断
12637565 MGI
acts upstream of or within cell migration IMP
IMP: 通过突变表型推断
12637565 MGI
acts upstream of or within ephrin receptor signaling pathway IMP
IMP: 通过突变表型推断
19505147 MGI
acts upstream of or within lamellipodium assembly IMP
IMP: 通过突变表型推断
12808099 MGI
involved in negative regulation of PERK-mediated unfolded protein response IGI
IGI: 通过遗传相互作用推断
14676213 MGI
involved in negative regulation of endoplasmic reticulum stress-induced eIF2 alpha phosphorylation IGI
IGI: 通过遗传相互作用推断
14676213 MGI
involved in negative regulation of transcription by RNA polymerase II IGI
IGI: 通过遗传相互作用推断
16835242 MGI
acts upstream of or within positive regulation of actin filament polymerization IGI
IGI: 通过遗传相互作用推断
17923684 MGI
involved in positive regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway IGI
IGI: 通过遗传相互作用推断
16835242 MGI
acts upstream of or within positive regulation of neuron projection development IMP
IMP: 通过突变表型推断
19505147 MGI
involved in positive regulation of translation in response to endoplasmic reticulum stress IGI
IGI: 通过遗传相互作用推断
14676213 MGI
acts upstream of or within regulation of cell migration IGI
IGI: 通过遗传相互作用推断
19505147 MGI
involved in response to endoplasmic reticulum stress IGI
IGI: 通过遗传相互作用推断
16835242 MGI
acts upstream of or within response to other organism IMP
IMP: 通过突变表型推断
22966049 MGI
acts upstream of or within substrate-dependent cell migration, cell extension IGI
IGI: 通过遗传相互作用推断
19414610 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell-cell junction IDA
IDA: 通过直接分析推断
23793062 MGI
located in vesicle membrane IDA
IDA: 通过直接分析推断
12147689 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

cytoplasmic protein NCK1

NCK adaptor protein 1

Nck1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
Nck1 Q99M51 Tnk2 Mus musculus O54967
Anti Bait CoIP
16777958
种属内
Nck1 Q99M51 Abl1 Mus musculus P00520
Anti Tag CoIP
15148308
种属内
Nck1 Q99M51 Dok1 Mus musculus P97465
Anti Tag CoIP
15148308
种属内
Nck1 Q99M51 Dok1 Mus musculus P97465
Pull Down
20697350
种属内
Nck1 Q99M51 Dok1 Mus musculus P97465
Anti Bait CoIP
15148308
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09080 NCK1 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS18777 Nck1 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS25265 Nck1 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nck1 NCBI NCBI:4690
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