2. Gene
  3. Notch3 - notch 3 Gene

Notch3 - notch 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: N3; hpbk

基因 ID: 18131 | 基因类型: protein coding

关于 Notch3

功能概要

Enables enzyme binding activity. Involved in Notch signaling pathway and positive regulation of smooth muscle cell proliferation. Acts upstream of or within several processes, including blood vessel morphogenesis; nervous system development; and regulation of transcription by RNA polymerase II. Located in nucleus and plasma membrane. Is expressed in several structures, including alimentary system; cardiovascular system; central nervous system; genitourinary system; and sensory organ. Used to study CADASIL 1 and acute lymphoblastic leukemia. Human ortholog(s) of this gene implicated in CADASIL 1; infantile myofibromatosis; and lateral meningocele syndrome. Orthologous to human NOTCH3 (Notch receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Notch3 基因产物(1)

mRNA Protein Name
NM_008716.3 NP_032742.1 neurogenic locus notch homolog protein 3 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables enzyme binding IPI
IPI: 通过物理相互作用推断
17573339 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9111338 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Notch signaling pathway IDA
IDA: 通过直接分析推断
19855400 MGI
acts upstream of or within artery morphogenesis IMP
IMP: 通过突变表型推断
23117660 MGI
acts upstream of or within forebrain development IGI
IGI: 通过遗传相互作用推断
16120638 MGI
involved in glomerular capillary formation IEP
IEP: 通过表达模式推断
15821257 MGI
acts upstream of or within negative regulation of cell differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of or within negative regulation of neuron differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of or within negative regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23117660 MGI
acts upstream of neuroblast differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of neuron differentiation IMP
IMP: 通过突变表型推断
15064243 MGI
acts upstream of or within neuron fate commitment IGI
IGI: 通过遗传相互作用推断
16120638 MGI
involved in positive regulation of smooth muscle cell proliferation IDA
IDA: 通过直接分析推断
19855400 MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
23117660 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nucleus IDA
IDA: 通过直接分析推断
21191019 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
17079689 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

neurogenic locus notch homolog protein 3

相关产品

Clinical Phase
生物活性分子 (2)
目录号 产品名 作用方式
纯度 Phase
HY-15670 BMS-906024 Inhibitor 99.91% Phase 1
HY-12860 BMS-986115 Inhibitor 99.90% Phase 1
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99320 Tarextumab Inhibitor 96.80% Phase 2
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15827 NSC 405020 Inhibitor 99.63% 否
HY-136522 S2116 98.05% 否
HY-RS09451 NOTCH3 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-136523 S2157 98.44% 否
HY-RS17213 Notch3 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23665 Notch3 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Notch3 NCBI NCBI:4854
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