2. Neuronal Signaling Stem Cell/Wnt
  3. Notch
  4. Tarextumab

Tarextumab  (Synonyms: 他瑞妥单抗; OMP 59R5; Anti-Human NOTCH2 Recombinant Antibody)

目录号: HY-P99320 纯度: 96.80%
COA 技术支持

Tarextumab (OMP-59R5) 是一种具有交叉反应性的全人源 IgG2 抗体，可选择性抑制 Notch2 和 Notch3 信号通路。Tarextumab 在上皮瘤的异种移植模型中表现出广谱抗肿瘤效力。Tarextumab 可用于胰腺癌研究。

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CAS No. : 1359940-55-8

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1 mg ￥2100
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Tarextumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tarextumab (OMP-59R5) is a cross-reactive, fully human IgG2 antibody that selectively inhibits Notch2 and Notch3 signaling. Tarextumab demonstrates broad-spectrum antitumor efficacy in xenograft models of epithelial tumors. Tarextumab can be used for the study of pancreatic cancer[1][2].

同型

Human IgG2 kappa
推荐同型对照抗体
反应种属

Human
IC50 & Target

NOTCH3
体外研究
(In Vitro)

Tarextumab 在 HeLa 细胞中通过 Notch 响应性荧光素酶报告基因实验抑制 Notch2 和 Notch3 信号活性，而不影响 Notch1[1]。
Tarextumab 下调人源 Notch2、Notch3、HES1、NANOG 和 OCT4 的 mRNA 表达，并逆转 OMP-PN17 胰腺肿瘤细胞中 Gemcitabine (HY-17026) 诱导的 EMT 相关基因(CDH2、VIM、FN1) 的上调[1]。
Tarextumab 降低 OMP-PN17 胰腺肿瘤细胞中 Notch3 细胞外结构域和活化的胞内结构域）的蛋白水平，并减少具有高 Notch3 ECD 染色的细胞数量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tarextumab 相关抗体:
体内研究
(In Vivo)

Tarextumab (40 mg/kg，腹腔注射，每两周一次) 联合 Gemcitabine (HY-17026) 可在 NOD/SCID 小鼠的胰腺癌 PDX 模型中抑制肿瘤生长并诱导肿瘤回归[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human pancreatic cancer cells (from PDX models including OMP-PN4, OMP-PN8, OMP-PN17) were subcutaneously implanted into NOD/SCID mice[1]
Dosage: 40 mg/kg combined with Gemcitabine (HY-17026)
Administration: i.p., every other week
Result: Achieved enhanced antitumor efficacy.
Showed striking tumor regression.
Reduced cancer stem cell (CSC) frequency.
Delayed tumor recurrence.
Decreased tumor cell proliferation.
Increased pericyte maturation (enhanced desmin-positive pericyte association with CD31-positive endothelial cells) and tumor vascular perfusion and reduced intratumoral hypoxia.
Animal Model: Triple-negative breast cancer (TNBC) cells (from cell lines including MDA-MB-468, HCC70) were subcutaneously implanted into BALB/c nude mice[2]
Dosage: 40 mg/kg
Administration: i.p., once weekly, 4 weeks
Result: Reduced tumor-initiating cell (TIC) frequency.
Clinical Trial
基因 ID

4854  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

142.94 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

他瑞妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG2 kappa
Biological Activity
  • Immobilized NOTCH2 Protein (His Tag), Human can bind Tarextumab. The EC50 for this effect is 1.22 ng/mL.
纯度 & 产品资料
参考文献

Tarextumab 相关分类

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tarextumab1359940-55-8OMP 59R5 Anti-Human NOTCH2 Recombinant Antibody他瑞妥单抗NotchNotch2Notch3cancerInhibitorinhibitorinhibit

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