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  2. Serpine1 - serine (or cysteine) peptidase inhibitor, clade E, member 1 Gene

Serpine1 - serine (or cysteine) peptidase inhibitor, clade E, member 1 Gene

中文名称:丝氨酸 (或半胱氨酸) 肽酶抑制因子,进化枝 E,成员 1

种属: Mus musculus

同用名: PAI1; PAI-1; Planh1

基因 ID: 18787 | 基因类型: protein coding

关于 Serpine1

Chromosome 5: 137,090,358-137,101,122 reverse strand.GRCm39:CM000998.3

This gene has 3 transcripts (splice variants), 187 orthologues, 63 paralogues and is associated with 44 phenotypes. Biased expression in placenta adult (RPKM 8.4), liver E18 (RPKM 11.4) and 3 other tissues.

功能概要

该基因编码的蛋白可启动丝氨酸型内肽酶抑制剂活性。参与对革兰氏阴性菌的防御反应;纤溶酶原激活的负调节;和血管生成的调节。作用于多个过程的上游或内部,包括细胞对转化生长因子 β 刺激的反应;胎盘发育;和血管生成的调节。位于细胞外空间。以多种结构表达,包括主动脉;胚外成分;肝;卵母细胞;和胎盘。用于研究冠状病毒传染病。该基因的人类直系同源物与多种疾病有关,包括动脉疾病(多种);自身免疫性疾病(多种);糖尿病视网膜病变(多发性);肝病(多发性);和肺部疾病(多种)。与人类 SERPINE1(丝氨酸蛋白酶抑制剂家族 E 成员 1)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]

Serpine1 基因产物(1)

mRNA Protein Name
NM_008871.2 NP_032897.2 plasminogen activator inhibitor 1 precursor

Serpine1 蛋白结构

serpin

serpin: cl38926 (28 - 401)

  • 0
  • 100
  • 200
  • 300
  • 402 a.a.
蛋白主名 其他名称

plasminogen activator inhibitor 1

PAI

Plasminogen activator inhibitor-1 precursor (PAI-1) (Endothelial plasminogen activator inhibitor) (PAI)

endothelial plasminogen activator inhibitor

nexin, plasminogen activator inhibitor type 1

plasminogen activator inhibitor, type I

serine (or cysteine) proteinase inhibitor, clade E, member 1

serpin E1

重组 Serpine1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71133 Serpin E1 Protein, Mouse (N172S, R253G, HEK293, His) P22777 (T23-P402, N172S, R253G) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Serpine1 NCBI NCBI:5054
Rattus norvegicus Serpine1 NCBI NCBI:24617