Serpine1 - serine (or cysteine) peptidase inhibitor, clade E, member 1 Gene

中文名称：丝氨酸 (或半胱氨酸) 肽酶抑制因子，进化枝 E，成员 1

种属: Mus musculus

同用名: PAI1; PAI-1; Planh1

关于 Serpine1

功能概要

该基因编码的蛋白可启动丝氨酸型内肽酶抑制剂活性。参与对革兰氏阴性菌的防御反应；纤溶酶原激活的负调节；和血管生成的调节。作用于多个过程的上游或内部，包括细胞对转化生长因子 β 刺激的反应；胎盘发育；和血管生成的调节。位于细胞外空间。以多种结构表达，包括主动脉；胚外成分；肝;卵母细胞;和胎盘。用于研究冠状病毒传染病。该基因的人类直系同源物与多种疾病有关，包括动脉疾病（多种）；自身免疫性疾病（多种）；糖尿病视网膜病变（多发性）；肝病（多发性）；和肺部疾病（多种）。与人类 SERPINE1（丝氨酸蛋白酶抑制剂家族 E 成员 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables serine-type endopeptidase inhibitor activity. Involved in defense response to Gram-negative bacterium; negative regulation of plasminogen activation; and regulation of angiogenesis. Acts upstream of or within several processes, including cellular response to transforming growth factor beta stimulus; placenta development; and regulation of angiogenesis. Located in extracellular space. Is expressed in several structures, including aorta; extraembryonic component; liver; oocyte; and placenta. Used to study Coronavirus infectious disease. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Orthologous to human SERPINE1 (serpin family E member 1). [provided by Alliance of Genome Resources, Apr 2022]