2. Gene
  3. Ptpn22 - protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Gene

Ptpn22 - protein tyrosine phosphatase, non-receptor type 22 (lymphoid) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: PEP; Ptpn8; 70zpep

基因 ID: 19260 | 基因类型: protein coding

关于 Ptpn22

功能概要

Enables SH3 domain binding activity and kinase binding activity. Involved in several processes, including regulation of T cell activation; regulation of cytokine production; and regulation of signal transduction. Acts upstream of or within T cell differentiation; T cell receptor signaling pathway; and protein dephosphorylation. Located in cytoplasm; cytoplasmic side of plasma membrane; and nucleus. Is expressed in dorsal root ganglion; peripheral nervous system; and thymus primordium. Human ortholog(s) of this gene implicated in several diseases, including Addison's disease; Meniere's disease; autoimmune disease (multiple); chronic lymphocytic leukemia; and pulmonary tuberculosis. Orthologous to human PTPN22 (protein tyrosine Phosphatase non-receptor type 22). [provided by Alliance of Genome Resources, Apr 2022]

Ptpn22 基因产物(3)

mRNA Protein Name
NM_001409794.1 NP_001396723.1 tyrosine-protein phosphatase non-receptor type 22 isoform 1
NM_001409795.1 NP_001396724.1 tyrosine-protein phosphatase non-receptor type 22 isoform 2
NM_008979.3 NP_033005.1 tyrosine-protein phosphatase non-receptor type 22 isoform 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables SH3 domain binding IPI
IPI: 通过物理相互作用推断
8890164 MGI
enables kinase binding IPI
IPI: 通过物理相互作用推断
8890164 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
15786712 MGI
enables protein tyrosine phosphatase activity IDA
IDA: 通过直接分析推断
27043286 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within T cell differentiation IMP
IMP: 通过突变表型推断
14752163 MGI
acts upstream of or within T cell receptor signaling pathway IMP
IMP: 通过突变表型推断
14752163 MGI
involved in cellular response to muramyl dipeptide IDA
IDA: 通过直接分析推断
23991106 MGI
involved in negative regulation of T cell activation IMP
IMP: 通过突变表型推断
21044313 MGI
involved in negative regulation of gene expression IMP
IMP: 通过突变表型推断
23871208 MGI
involved in negative regulation of interleukin-6 production IMP
IMP: 通过突变表型推断
23991106 MGI
involved in negative regulation of interleukin-8 production IMP
IMP: 通过突变表型推断
23991106 MGI
involved in negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway IMP
IMP: 通过突变表型推断
23991106 MGI
involved in negative regulation of p38MAPK cascade IMP
IMP: 通过突变表型推断
23991106 MGI
involved in negative regulation of tumor necrosis factor production IMP
IMP: 通过突变表型推断
23991106 MGI
involved in phosphoanandamide dephosphorylation IDA
IDA: 通过直接分析推断
16938887 MGI
involved in positive regulation of CD8-positive, alpha-beta T cell proliferation IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of ERK1 and ERK2 cascade IMP
IMP: 通过突变表型推断
23991106 MGI
involved in positive regulation of NLRP3 inflammasome complex assembly IDA
IDA: 通过直接分析推断
27043286 MGI
involved in positive regulation of defense response to virus by host IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of granzyme B production IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of interferon-alpha production IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of interferon-beta production IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of protein K63-linked ubiquitination IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of protein import into nucleus IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of toll-like receptor 3 signaling pathway IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of toll-like receptor 4 signaling pathway IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of toll-like receptor 7 signaling pathway IMP
IMP: 通过突变表型推断
23871208 MGI
involved in positive regulation of toll-like receptor 9 signaling pathway IMP
IMP: 通过突变表型推断
23871208 MGI
acts upstream of or within protein dephosphorylation IMP
IMP: 通过突变表型推断
14752163 MGI
involved in protein dephosphorylation IMP
IMP: 通过突变表型推断
1373816 MGI
NOT involved in regulation of antigen processing and presentation IMP
IMP: 通过突变表型推断
23871208 MGI
involved in regulation of leukocyte migration IMP
IMP: 通过突变表型推断
23871208 MGI
involved in regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
23991106 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
8890164 MGI
located in cytoplasmic side of plasma membrane IDA
IDA: 通过直接分析推断
10940933 MGI
located in nucleus IDA
IDA: 通过直接分析推断
10940933 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

tyrosine-protein phosphatase non-receptor type 22

PEST domain-enriched tyrosine phosphatase

hematopoietic cell protein-tyrosine phosphatase 70Z-PEP

protein tyrosine phosphatase, non-receptor type 8

相关产品

Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-139693 PTPN22-IN-1 Inhibitor 99.89% 否
HY-155848 LYP-IN-4 Inhibitor 98.09% 否
HY-170564 PTPN22-IN-2 Inhibitor / 否
HY-RS11424 PTPN22 Human Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS17516 Ptpn22 Mouse Pre-designed siRNA Set A Pre-designed Set / 否
HY-RS23973 Ptpn22 Rat Pre-designed siRNA Set A Pre-designed Set / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Ptpn22 NCBI NCBI:26191
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