2. Gene
  3. Rad51 - RAD51 recombinase Gene

Rad51 - RAD51 recombinase Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：RAD51 重组酶

种属: Mus musculus

同用名: Reca; Rad51a

基因 ID: 19361 | 基因类型: protein coding

关于 Rad51

Chromosome 2: 118,943,274-118,977,926 forward strand.GRCm39:CM000995.3

This gene has 8 transcripts (splice variants), 220 orthologues, 6 paralogues and is associated with 11 phenotypes. Biased expression in placenta adult (RPKM 14.2), liver E14 (RPKM 13.5) and 13 other tissues.

功能概要

该基因编码的蛋白可启动染色质结合活性和单链 DNA 结合活性。通过重组参与端粒维护和通过端粒延长参与端粒维护。作用于多个过程的上游或内部，包括 DNA 代谢过程；细胞对羟基脲的反应；和染色体组织。位于染色体端粒区；细胞质；和横向元素。以多种结构表达，包括大脑；压实的桑葚;性腺;淋巴系统；和椎旁神经节。该基因的人类直系同源物涉及范可尼贫血互补组 R；乳腺癌;先天性镜像运动障碍；和卵巢癌。与人 RAD51 同源（RAD51 重组酶）。 [由基因组资源联盟提供，2022 年 4 月]

Enables chromatin binding activity and single-stranded DNA binding activity. Involved in telomere maintenance via recombination and telomere maintenance via telomere lengthening. Acts upstream of or within several processes, including DNA metabolic process; cellular response to hydroxyurea; and chromosome organization. Located in chromosome, telomeric region; cytoplasm; and lateral element. Is expressed in several structures, including brain; compacted morula; gonad; hemolymphoid system; and paravertebral ganglion. Human ortholog(s) of this gene implicated in Fanconi anemia complementation group R; breast cancer; congenital mirror movement disorder; and ovarian Cancer. Orthologous to human RAD51 (RAD51 recombinase). [provided by Alliance of Genome Resources, Apr 2022]

Rad51 基因产物(1)

mRNA Protein Name
NM_011234.5 NP_035364.1 DNA repair protein RAD51 homolog 1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA strand exchange activity IDA
IDA: 通过直接分析推断
15834424 MGI
enables chromatin binding IDA
IDA: 通过直接分析推断
24108124 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
9126738 MGI
enables single-stranded DNA binding IDA
IDA: 通过直接分析推断
22778135 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within cellular response to alkaloid IMP
IMP: 通过突变表型推断
22778135 MGI
acts upstream of or within cellular response to hydroxyurea IMP
IMP: 通过突变表型推断
22778135 MGI
acts upstream of or within chromosome organization involved in meiotic cell cycle IMP
IMP: 通过突变表型推断
22778135 MGI
involved in double-strand break repair involved in meiotic recombination IDA
IDA: 通过直接分析推断
15834424 MGI
acts upstream of or within double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
15359272 MGI
involved in double-strand break repair via homologous recombination IDA
IDA: 通过直接分析推断
15834424 MGI
acts upstream of or within double-strand break repair via homologous recombination IMP
IMP: 通过突变表型推断
15485900 MGI
acts upstream of or within meiotic cell cycle IDA
IDA: 通过直接分析推断
10809667 MGI
involved in reciprocal meiotic recombination IDA
IDA: 通过直接分析推断
15834424 MGI
acts upstream of or within regulation of protein phosphorylation IMP
IMP: 通过突变表型推断
22778135 MGI
acts upstream of or within replication fork processing IMP
IMP: 通过突变表型推断
22778135 MGI
acts upstream of or within replication-born double-strand break repair via sister chromatid exchange IMP
IMP: 通过突变表型推断
22778135 MGI
involved in telomere maintenance via recombination IGI
IGI: 通过遗传相互作用推断
21076401 MGI
involved in telomere maintenance via telomere lengthening IGI
IGI: 通过遗传相互作用推断
21076401 MGI
acts upstream of or within telomere organization IMP
IMP: 通过突变表型推断
22778135 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in chromosome IDA
IDA: 通过直接分析推断
30272023 MGI
located in chromosome, telomeric region IDA
IDA: 通过直接分析推断
21076401 MGI
located in condensed chromosome IDA
IDA: 通过直接分析推断
10809667 MGI
located in condensed nuclear chromosome IDA
IDA: 通过直接分析推断
14668445 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
29955025 MGI
located in lateral element IDA
IDA: 通过直接分析推断
18694567 MGI
located in male germ cell nucleus IDA
IDA: 通过直接分析推断
23133398 MGI
located in nucleus IDA
IDA: 通过直接分析推断
8816780 MGI
is active in site of double-strand break IDA
IDA: 通过直接分析推断
30760716 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Rad51 蛋白结构

recomb_RAD51

recomb_RAD51: TIGR02239 (24 - 338)

  • 0
  • 100
  • 200
  • 300
  • 339 a.a.
蛋白主名 其他名称

DNA repair protein RAD51 homolog 1

RAD51 homolog A

相关产品

Clinical Phase
生物活性分子 (4)
目录号 产品名 作用方式
纯度 Phase
HY-19793 RS-1 Activator 99.77% Phase 2
HY-10206 Amuvatinib Inhibitor 99.40% Phase 2
HY-111887 Emzadirib Inhibitor 99.63% Phase 2
HY-10206A Amuvatinib hydrochloride Inhibitor / Phase 2
Pre-clinical Phase
生物活性分子 (33)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-D0086 DIDS sodium salt Inhibitor 99.13% 否
HY-101462 RAD51 Inhibitor B02 Inhibitor 99.89% 否
HY-15317 RI-1 Inhibitor 99.83% 否
HY-103710 IBR2 Inhibitor 98.24% 否
HY-150147 CAM833 Inhibitor 99.83% 否
HY-126020 Bractoppin Inhibitor 99.90% 否
HY-N3980 Guaiol 99.67% 否
HY-N7271 Solanidine Inhibitor 99.90% 否
HY-148183 Homologous recombination-IN-1 Inhibitor 98.65% 否
HY-16904 RI-2 Inhibitor 99.90% 否
HY-122705 RAD51-IN-1 Inhibitor 99.89% 否
HY-126972A RI(dl)-2 TFA Inhibitor 98.02% 否
HY-136604 RAD51-IN-3 Inhibitor 99.24% 否
HY-143736 RAD51-IN-5 Inhibitor 98.87% 否
HY-176549 (Rac)-IBR120 Inhibitor / 否
HY-143737 RAD51-IN-6 Inhibitor / 否
HY-143735 RAD51-IN-4 Inhibitor / 否
HY-143741 RAD51-IN-7 Inhibitor / 否
HY-150958 RAD51-IN-8 / 否
HY-178022 HDAC6-IN-63 Inhibitor / 否
HY-126972 RI(dl)-2 Inhibitor / 否
HY-P10516 BRC4 peptide / 否
HY-121693 DIDS Inhibitor / 否
HY-169213 LN-439A Inhibitor / 否
HY-170907 HDAC-IN-85 Inducer / 否
HY-N7271R Solanidine (Standard) Inhibitor / 否
HY-178021 HDAC1-IN-11 Inhibitor / 否
HY-122583 D-G23 Inhibitor / 否
HY-103710A (R)-IBR2 Control / 否
HY-173345 BRCA2-RAD51-IN-2 Inhibitor / 否
HY-172252 CSN5-IN-2 Inhibitor / 否
HY-169622 RAD51-IN-9 Inhibitor / 否
HY-162104 BRCA2-RAD51-IN-1 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Rad51 NCBI NCBI:5888
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