1. Gene
  2. Tfeb - transcription factor EB Gene

Tfeb - transcription factor EB Gene

种属: Mus musculus

同用名: Tcfeb; bHLHe35

基因 ID: 21425 | 基因类型: protein coding

关于 Tfeb

功能概要

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and protein heterodimerization activity. Involved in several processes, including defense response to Gram-negative bacterium; embryonic placenta development; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within lysosome organization and positive regulation of transcription, DNA-templated. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including cardiovascular system; central nervous system; early conceptus; genitourinary system; and gut gland. Orthologous to human TFEB (transcription factor EB). [provided by Alliance of Genome Resources, Apr 2022]

Tfeb 基因产物(3)

mRNA Protein Name
NM_001161722.1 NP_001155194.1 transcription factor EB isoform b
NM_001161723.1 NP_001155195.1 transcription factor EB isoform b
NM_011549.3 NP_035679.3 transcription factor EB isoform a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables DNA binding IDA
IDA: 通过直接分析推断
15994295 MGI
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
IDA: 通过直接分析推断
16936731 MGI
enables DNA-binding transcription factor activity IDA
IDA: 通过直接分析推断
16936731 MGI
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
IDA: 通过直接分析推断
16936731 MGI
enables protein heterodimerization activity IPI
IPI: 通过物理相互作用推断
16936731 MGI
enables transcription cis-regulatory region binding IDA
IDA: 通过直接分析推断
16936731 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in defense response to Gram-negative bacterium IMP
IMP: 通过突变表型推断
27184844 MGI
involved in embryonic placenta development IMP
IMP: 通过突变表型推断
9806910 MGI
involved in humoral immune response IMP
IMP: 通过突变表型推断
16936731 MGI
acts upstream of or within lysosome organization IMP
IMP: 通过突变表型推断
31637311 MGI
acts upstream of or within positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
15994295 MGI
involved in positive regulation of DNA-templated transcription IDA
IDA: 通过直接分析推断
29146937 MGI
involved in positive regulation of transcription by RNA polymerase II IDA
IDA: 通过直接分析推断
16936731 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
27184844 MGI
colocalizes with nucleus IDA
IDA: 通过直接分析推断
27184844 MGI
located in nucleus IDA
IDA: 通过直接分析推断
27184844 MGI
part of transcription regulator complex IDA
IDA: 通过直接分析推断
15994295 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

transcription factor EB

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Tfeb NCBI NCBI:7942